Document Detail

Proton magnetic resonance spectroscopy of normal appearing white matter in asymptomatic relatives of multiple sclerosis patients.
MedLine Citation:
PMID:  16618349     Owner:  NLM     Status:  MEDLINE    
Proton magnetic resonance spectroscopy of normal appearing white matter (NAWM) was performed in 25 first-degree relatives of patients with multiple sclerosis (MS). In relatives of MS patients, insignificant trends in the NAA/Cho ratio (to be lower) and in the Cho/Cr ratio (to be higher) were found when compared with healthy controls. These results demonstrated that there are only minimal, insignificant changes in commonly identified metabolite concentrations in NAWM of relatives of MS patients when compared with healthy subjects.
M Siger-Zajdel; K Selmaj
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of neurology : the official journal of the European Federation of Neurological Societies     Volume:  13     ISSN:  1351-5101     ISO Abbreviation:  Eur. J. Neurol.     Publication Date:  2006 Mar 
Date Detail:
Created Date:  2006-04-18     Completed Date:  2006-06-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9506311     Medline TA:  Eur J Neurol     Country:  England    
Other Details:
Languages:  eng     Pagination:  296-8     Citation Subset:  IM    
Department of Neurology, Medical University of Lodz, Lodz, Poland.
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MeSH Terms
Aspartic Acid / analogs & derivatives,  metabolism
Choline / metabolism
Creatine / metabolism
Magnetic Resonance Imaging
Magnetic Resonance Spectroscopy*
Multiple Sclerosis / classification,  complications,  metabolism,  pathology*
Reg. No./Substance:
0/Protons; 56-84-8/Aspartic Acid; 57-00-1/Creatine; 62-49-7/Choline

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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