| Proton magnetic resonance spectroscopy (1H-MRS) of motor cortex and basal ganglia in de novo Parkinson's disease patients. | |
| | |
MedLine Citation:
|
PMID: 11487206 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Proton MR spectroscopy (1H-MRS) has been previously performed in Parkinson's disease (PD) and parkinsonian syndromes to evaluate in vivo concentrations of basal ganglia and cerebral cortex metabolites such as N-acetylaspartate (NAA), choline (Cho), and creatine (Cr). However, this technique has never been used to evaluate motor cortex in untreated PD patients. In this study, single-voxel 1H-MRS of basal ganglia and motor cortex was carried out in 10 de novo patients with PD and 10 age-matched healthy controls. A significant reduction in the NAA/Cr ratio was observed in the motor cortex of PD patients compared with controls (p)<(0.01). Basal ganglia spectra did not allow any evaluation due to the presence of artefacts related to inorganic paramagnetic substances. The motor cortex reduction of the NAA/Cr ratio in de novo PD patients may reflect an altered neuronal functioning due to a loss of thalamocortical excitatory inputs and may represent an in vivo marker for the diagnosis of PD. |
| | |
Authors:
|
C Lucetti; P Del Dotto; G Gambaccini; S Bernardini; M C Bianchi; M Tosetti; U Bonuccelli |
Related Documents
:
|
15545016 - Studies on homocysteine and dehydroepiandrosterone sulphate plasma levels in alzheimer'... 11685496 - Striatal dopamine transporter function in dementia with lewy bodies and parkinson's dis... 21923476 - Synovial and serum levels of uncarboxylated matrix gla-protein (ucmgp) in patients with... 3830206 - Cardiovascular reflexes in parkinson's disease. 17922806 - Fibrinolysis in patients with an abdominal aortic aneurysm with special emphasis on rup... 11316216 - The ringed esophagus: histological features of gerd. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology Volume: 22 ISSN: 1590-1874 ISO Abbreviation: Neurol. Sci. Publication Date: 2001 Feb |
Date Detail:
|
Created Date: 2001-08-06 Completed Date: 2001-12-13 Revised Date: 2004-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 100959175 Medline TA: Neurol Sci Country: Italy |
Other Details:
|
Languages: eng Pagination: 69-70 Citation Subset: IM |
Affiliation:
|
Department of Neuroscience, University of Pisa, Italy. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Aspartic Acid / analogs & derivatives*, metabolism Basal Ganglia / metabolism*, physiopathology Brain Chemistry / physiology Choline / metabolism Creatine / metabolism Female Humans Inositol / metabolism Magnetic Resonance Spectroscopy* Male Middle Aged Motor Cortex / metabolism*, physiopathology Parkinson Disease / diagnosis*, metabolism*, physiopathology |
| Chemical | |
Reg. No./Substance:
|
56-84-8/Aspartic Acid; 57-00-1/Creatine; 62-49-7/Choline; 6917-35-7/Inositol; 997-55-7/N-acetylaspartate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Deep brain stimulation of the subthalamic nucleus: selection of patients and clinical results.
Next Document: Interaction between dopamine and adenosine A2A receptors as a basis for the treatment of Parkinson's...