| Proton magnetic resonance spectroscopic imaging in patients with extratemporal epilepsy. | |
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MedLine Citation:
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PMID: 9578043 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: Reduced levels of N-acetylaspartate (NAA) in temporal lobes responsible for temporal lobe epilepsy have been observed consistently in proton magnetic resonance spectroscopy (MRS) studies. METHODS: We investigated the potential of proton MRS to detect low NAA outside of the temporal lobes in patients with non-lesional partial extratemporal epilepsy. Proton MR spectroscopic imaging (MRSI) data of both frontal lobes and central/postcentral regions were obtained in 20 such patients and 16 normal control subjects. The epileptogenic region was determined by an extensive clinical-EEG investigation, including the recording of habitual seizures in each patient, and intracranial EEG recordings in 10 patients. RESULTS: The relative NAA resonance intensities (i.e., NAA/phosphocreatine plus creatine (CR(t)), NAA/choline-containing metabolites (Cho(t)) and NAA/Cr(t) + Cho(t)), were all significantly reduced throughout the spectroscopic image as compared with that of the controls. Furthermore, reduction of the NAA ratios was greater in the epileptogenic region as compared with the nonepileptogenic regions, on EEG investigation. CONCLUSIONS: In vivo proton MRSI of patients with nonlesional partial extratemporal epilepsy detected evidence of widespread neuronal damage or dysfunction that was greatest in the region of seizure focus. |
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Authors:
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J A Stanley; F Cendes; F Dubeau; F Andermann; D L Arnold |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Epilepsia Volume: 39 ISSN: 0013-9580 ISO Abbreviation: Epilepsia Publication Date: 1998 Mar |
Date Detail:
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Created Date: 1998-05-22 Completed Date: 1998-05-22 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 2983306R Medline TA: Epilepsia Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 267-73 Citation Subset: IM |
Affiliation:
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Montreal Neurological Institute and Hospital, McGill University, Quebec, Canada. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aspartic Acid / analogs & derivatives, metabolism Cerebral Cortex / metabolism* Choline / metabolism Electrodes, Implanted Epilepsies, Partial / diagnosis*, metabolism Epilepsy, Frontal Lobe / diagnosis, metabolism Female Humans Magnetic Resonance Spectroscopy / diagnostic use* Male Phosphocreatine / metabolism Protons |
| Chemical | |
Reg. No./Substance:
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0/Protons; 56-84-8/Aspartic Acid; 62-49-7/Choline; 67-07-2/Phosphocreatine; 997-55-7/N-acetylaspartate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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