| Proton leak and control of oxidative phosphorylation in perfused, resting rat skeletal muscle. | |
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MedLine Citation:
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PMID: 8764890 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The distribution of control over the resting respiration rate (and other variables) was assessed in perfused rat skeletal muscle. The results indicate that the general pattern of control in resting muscle is similar to that seen in isolated rat liver cells (Brown et al. (1990) Biochem. J. 192, 355-362). Control over resting mitochondrial oxygen consumption was distributed between reactions involved in substrate oxidation (flux control coefficient = 0.44 +/- 0.28) and those involved in ATP turnover (0.21 +/- 0.09). The mitochondrial proton leak also had an important share of the control (0.38 +/- 0.21). Since proton leak also has significant control over the resting respiration rate of isolated liver cells and liver and skeletal muscle account for around 60% of the standard metabolic rate of a rat, then these results indicate the potential importance of proton leak as a mechanism of regulating metabolic rate. |
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Authors:
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D F Rolfe; M D Brand |
Publication Detail:
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Type: In Vitro; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Biochimica et biophysica acta Volume: 1276 ISSN: 0006-3002 ISO Abbreviation: Biochim. Biophys. Acta Publication Date: 1996 Aug |
Date Detail:
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Created Date: 1996-09-19 Completed Date: 1996-09-19 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0217513 Medline TA: Biochim Biophys Acta Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 45-50 Citation Subset: IM |
Affiliation:
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Department of Biochemistry, University of Cambridge, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Female Kinetics Mitochondria, Muscle / metabolism Muscle, Skeletal / metabolism* Oxidative Phosphorylation Oxygen Consumption Perfusion Protons Rats Rats, Wistar |
| Chemical | |
Reg. No./Substance:
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0/Protons |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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