Document Detail

Proton computed tomography applied to small biomedical samples.
MedLine Citation:
PMID:  24254697     Owner:  NLM     Status:  In-Data-Review    
The computed tomography (CT) using the high-energy proton beam has the potential advantage of superior density resolution in the soft tissue analysis as compared to the conventional X-ray CT.We have developed the "first generation" type proton CT system using a 25-MeV proton beam to study the density distributions in small biomedical samples (<6 mm ϕ).The specimens were fixed in a cylindrical sample holder that was immersed in a water bath. The sample holder was scanned in front of the external semimicro beam of protons with a width of 0.06 mm at full width of half maximum (FWHM). The residual energy of the penetrated proton beam was analyzed with a solid state detector (SSD). The obtained integral density projection views were reconstructed into the density image by the filtered back projection method using the Shepp-Logan filter function.The spatial resolution of 0.1 mm and the density resolution of 0.1% were obtained by our system.The technique was applied to the eyes of small animals to study the changes in the density distributions of lenses, which develop with lens opacification in cataracts.
A Ito; H Koyama-Ito
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biological trace element research     Volume:  13     ISSN:  0163-4984     ISO Abbreviation:  Biol Trace Elem Res     Publication Date:  1987 Aug 
Date Detail:
Created Date:  2013-11-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7911509     Medline TA:  Biol Trace Elem Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  423     Citation Subset:  -    
Cyclotron Lab., Institute of Medical Science, Tokyo Univ., 4-6-1 Minato-ku, 108, Tokyo, Japan.
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