| Proton-actuated membrane-destabilizing polyion complex micelles. | |
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MedLine Citation:
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PMID: 17402703 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The efficiency of nucleic acid-based drugs is usually hampered by the fact that, following their uptake by the cell, these drugs end up in acidic organelles (i.e., endosomes/lysosomes) from which they barely escape. This work relates to the preparation and characterization of polyion complex micelles (PICM) formed by the self-assembly of three polyelectrolytes: a diblock cationic copolymer; a membranolytic, methacrylic acid copolymer; and an oligonucleotide. It is demonstrated that a synthetic membrane-active polyanion can be successfully integrated within the structure of PICM to yield well-defined, narrowly distributed micelles (30 nm) with a core/shell architecture. Besides their ability to protect the oligonucleotide against nuclease degradation, PICM partly dissociate under mildly acidic conditions, releasing chain clusters that destabilize bilayer membranes. This association/dissociation behavior illustrates the potential of these pH-sensitive PICM for the transport and efficient delivery of polyionic drugs. |
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Authors:
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Marie-Andrée Yessine; Marie-Hélène Dufresne; Christian Meier; Hans-Ulrich Petereit; Jean-Christophe Leroux |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2007-04-03 |
Journal Detail:
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Title: Bioconjugate chemistry Volume: 18 ISSN: 1043-1802 ISO Abbreviation: Bioconjug. Chem. Publication Date: 2007 May-Jun |
Date Detail:
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Created Date: 2007-05-16 Completed Date: 2007-08-29 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9010319 Medline TA: Bioconjug Chem Country: United States |
Other Details:
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Languages: eng Pagination: 1010-4 Citation Subset: IM |
Affiliation:
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Canada Research Chair in Drug Delivery, Faculty of Pharmacy, Université de Montréal, C.P. 6128 Succ. Centre-Ville, Montreal, Quebec, H3C 3J7, Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cell Line, Tumor Drug Delivery Systems* Endosomes / metabolism Humans Hydrogen-Ion Concentration Intracellular Membranes / drug effects, metabolism Micelles* Oligodeoxyribonucleotides / chemistry*, metabolism Polymethacrylic Acids / chemistry*, pharmacology Protons* |
| Chemical | |
Reg. No./Substance:
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0/Micelles; 0/Oligodeoxyribonucleotides; 0/Polymethacrylic Acids; 0/Protons |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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