| Proton pump inhibitors and pain. | |
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MedLine Citation:
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PMID: 19935988 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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There may be a relationship between proton pump inhibitors (PPIs) and iron absorption. PPIs may decrease the amount of iron absorbed gastrointestinally specifically due to alteration of the pH in the duodenum. Restless legs syndrome (RLS) is a sensorimotor disorder that includes an urge to move legs, accompanied or caused by uncomfortable and unpleasant sensations in the legs; the urge to move begins or worsens during periods of rest or inactivity, the urge to move is partially or totally relieved by movement, and the urge is worse or only occurs at night. In the majority of the restless leg syndrome population, the sensation is deep seated, often described as being in the shin bones, and most commonly felt between the knee and ankle. It may be described as a creepy, shock-like, tense, electric, buzzing, itchy, or even numb sensation. A subpopulation of this restless leg syndrome patient population experiences restless leg syndrome associated pain (RLSAP) that has been described as a deep "achy pain." This pain has not been found to be relieved by many of the typical over the counter analgesics. Often, constant movement of the legs appears to be the only remedy, as these sensations usually appear during periods of rest. Furthermore, there appears to be an association between iron deficiency and those suffering from Restless Leg Syndrome (RLS). The authors theorize that there may be a possible correlation between PPIs and the symptoms (e.g. pain) associated with RLS. The authors propose that PPIs, such as omeprazole, may interfere with iron absorption in certain patients and that a subpopulation of patients who develop significant iron deficiency characterized by low serum ferritin levels while on PPIs may also develop RLS-like symptoms (including RLSAP). While there is no robust direct evidence to support any associations of PPIs and iron deficiency or PPIs associated with RLS-like symptoms (including RLSAP), it is hoped that this manuscript may spark research efforts on this issue. |
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Authors:
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Howard S Smith; Reena Dhingra; Lori Ryckewaert; Dave Bonner |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Pain physician Volume: 12 ISSN: 2150-1149 ISO Abbreviation: Pain Physician Publication Date: 2009 Nov-Dec |
Date Detail:
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Created Date: 2009-11-25 Completed Date: 2010-02-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100954394 Medline TA: Pain Physician Country: United States |
Other Details:
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Languages: eng Pagination: 1013-23 Citation Subset: IM |
Affiliation:
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Albany Medical College, Department of Anesthesiology, Albany, NY 12208, USA. smithh@mail.amc.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Analgesics, Opioid
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metabolism Animals Humans Iron / deficiency, metabolism Neuralgia / complications, drug therapy*, etiology Proton Pump Inhibitors / pharmacology, therapeutic use* Restless Legs Syndrome / complications, drug therapy*, etiology |
| Chemical | |
Reg. No./Substance:
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0/Analgesics, Opioid; 0/Proton Pump Inhibitors; 7439-89-6/Iron |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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