| Proton pump inhibitor-induced hypocalcemic seizure in a patient with hypoparathyroidism. | |
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MedLine Citation:
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PMID: 21041166 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Objective: To report a case of proton pump inhibitor-induced hypocalcemic seizure in a patient with hypoparathyroidism.Methods: We describe the clinical history, physical examination findings, and laboratory values of the patient and briefly review the relevant literature.Results: A 48-year-old woman with a history of postsurgical hypoparathyroidism who was taking calcium carbonate, 1500 mg 3 times daily, and cholecalciferol, 1200 IU daily, presented with a generalized seizure in the setting of hypocalcemia 12 days after initiating therapy with the proton pump inhibitor lansoprazole. Physical examination revealed a positive Chvostek sign. Electrocardiogram was notable for a prolonged QTc interval of 576 milliseconds. Laboratory data were notable for the following values: total serum calcium, 5.3 mg/dL; ionized calcium, 2.51 mg/dL; and intact parathyroid hormone, 5.8 pg/mL. The patient's condition responded to therapy with intravenous calcium gluconate, oral calcium carbonate, and calcitriol. As an outpatient she remained asymptomatic off lansoprazole, treated with calcium carbonate and calcitriol.Conclusions: Caution should be exercised in prescribing proton pump inhibitors to patients with a history of hypoparathyroidism treated with calcium carbonate supplementation because severe hypocalcemia is a potential adverse effect. |
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Authors:
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Sofiya Milman; Eric J Epstein |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists Volume: 17 ISSN: 1934-2403 ISO Abbreviation: Endocr Pract Publication Date: 2011 Jan-Feb |
Date Detail:
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Created Date: 2011-02-10 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9607439 Medline TA: Endocr Pract Country: United States |
Other Details:
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Languages: eng Pagination: 104-7 Citation Subset: IM |
Affiliation:
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Department of Medicine, Division of Endocrinology, Diabetes, and Metabolism, Montefiore Medical Center and Albert Einstein College of Medicine, Bronx, New York. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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