Document Detail

Proton NMR spectroscopy of the phospholipids in human uterine smooth muscle and placenta.
MedLine Citation:
PMID:  9813438     Owner:  NLM     Status:  MEDLINE    
The parameters regulating the fluidity of myometrial and placental phospholipids include double bonds, fatty acid chain lenght and the cholesterol/phospholipid ratio. The transformation of these parameters was studied during pregnancy and labor. Myometrial and placental tissue samples were collected from 24 patients: 6 were nonpregnant, 6 early-pregnant, 6 late-pregnant not in labor and 6 in labor. After butanol extraction, tissue cholesterol and lipid phosphorus were determined. Proton NMR spectroscopy of the phospholipids was performed at 500 MHz. The myometrial cholesterol/phospholipid ratio was slightly elevated in pregnant patients not in labor. The uterine muscle of the nonpregnant patients contained more CH=CH groups in the phospholipids than that of the late-pregnant patients. There were 29 more double bonds in placental than in uterine tissue per 100 fatty acid molecules. The average fatty acid chain length varied from 14.0 to 18.8. The placenta has longer fatty acid chains than the uterine smooth muscle. The myometrial carbon chain was shortened on the average by 1.4 and the placental by 1.0 carbon atoms, when the patient went into clinical labor. These findings suggest fluidity changes in myometrial and placental phospholipids during human pregnancy and labor.
M O Pulkkinen; S Nyman; M M Hämäläinen; J Mattinen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Gynecologic and obstetric investigation     Volume:  46     ISSN:  0378-7346     ISO Abbreviation:  Gynecol. Obstet. Invest.     Publication Date:  1998  
Date Detail:
Created Date:  1999-01-06     Completed Date:  1999-01-06     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7900587     Medline TA:  Gynecol Obstet Invest     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  220-4     Citation Subset:  IM    
Department of Obstetrics and Gynecology, University of Turku, Turku, Finland.
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MeSH Terms
Cholesterol / analysis
Fatty Acids / analysis,  chemistry
Labor, Obstetric / physiology
Magnetic Resonance Spectroscopy
Membrane Fluidity
Muscle, Smooth / chemistry*
Myometrium / chemistry*
Phospholipids / analysis*,  chemistry
Placenta / chemistry*
Reg. No./Substance:
0/Butanols; 0/Fatty Acids; 0/Phospholipids; 57-88-5/Cholesterol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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