| Proton NMR spectroscopy of the phospholipids in human uterine smooth muscle and placenta. | |
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MedLine Citation:
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PMID: 9813438 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The parameters regulating the fluidity of myometrial and placental phospholipids include double bonds, fatty acid chain lenght and the cholesterol/phospholipid ratio. The transformation of these parameters was studied during pregnancy and labor. Myometrial and placental tissue samples were collected from 24 patients: 6 were nonpregnant, 6 early-pregnant, 6 late-pregnant not in labor and 6 in labor. After butanol extraction, tissue cholesterol and lipid phosphorus were determined. Proton NMR spectroscopy of the phospholipids was performed at 500 MHz. The myometrial cholesterol/phospholipid ratio was slightly elevated in pregnant patients not in labor. The uterine muscle of the nonpregnant patients contained more CH=CH groups in the phospholipids than that of the late-pregnant patients. There were 29 more double bonds in placental than in uterine tissue per 100 fatty acid molecules. The average fatty acid chain length varied from 14.0 to 18.8. The placenta has longer fatty acid chains than the uterine smooth muscle. The myometrial carbon chain was shortened on the average by 1.4 and the placental by 1.0 carbon atoms, when the patient went into clinical labor. These findings suggest fluidity changes in myometrial and placental phospholipids during human pregnancy and labor. |
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Authors:
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M O Pulkkinen; S Nyman; M M Hämäläinen; J Mattinen |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Gynecologic and obstetric investigation Volume: 46 ISSN: 0378-7346 ISO Abbreviation: Gynecol. Obstet. Invest. Publication Date: 1998 |
Date Detail:
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Created Date: 1999-01-06 Completed Date: 1999-01-06 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7900587 Medline TA: Gynecol Obstet Invest Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 220-4 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology, University of Turku, Turku, Finland. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Butanols Cholesterol / analysis Fatty Acids / analysis, chemistry Female Humans Labor, Obstetric / physiology Magnetic Resonance Spectroscopy Membrane Fluidity Muscle, Smooth / chemistry* Myometrium / chemistry* Phospholipids / analysis*, chemistry Placenta / chemistry* Pregnancy |
| Chemical | |
Reg. No./Substance:
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0/Butanols; 0/Fatty Acids; 0/Phospholipids; 57-88-5/Cholesterol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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