Document Detail

Proton MRS imaging in the follow-up of patients with suspected low-grade gliomas.
MedLine Citation:
PMID:  16133483     Owner:  NLM     Status:  MEDLINE    
We compared the value of changes in proton magnetic resonance spectroscopic imaging ((1)H-MRSI) with changes in clinical status and/or contrast-enhanced magnetic resonance imaging (MRI) in the monitoring of patients with suspected low-grade glioma (LGG). From June 1, 1999 till May 31, 2002, we included consecutive, neurologically intact adult patients suspected of having an LGG, demonstrating non-enhancing supratentorial lesions without edema or mass effect on MRI, and in whom all treatment (including a diagnostic biopsy) was deferred. Till January 1, 2003, patients were surveyed clinically and radiologically (contrast-enhanced MRI and (1)H-MRSI). Patients who showed progression on clinical examination and/or MRI were denoted as progressive disease. Other patients were denoted as stable disease. A decrease in NAA/CHO ratio of > or =20% compared to the baseline value was considered as indicative for progression on (1)H-MRSI. We included 14 patients with suspected LGG. Seven patients demonstrated progressive disease during the follow-up period, preceded or accompanied by concomitant (1)H-MRSI changes in five patients. Four of these five patients were operated on within the follow-up interval. The histological diagnosis demonstrated high-grade glioma in three and LGG in one patient. In the other two patients with progressive disease, no progression was found on (1)H-MRSI. The other seven patients demonstrated stable disease, but four of them showed progression on (1)H-MRSI. Our data do not show convincing evidence that (1)H-MRSI contributes to adequate monitoring and follow-up of patients with suspected LGG. Future research should preferably include pathological data at the time of (1)H-MRSI changes.
J C Reijneveld; J van der Grond; L M P Ramos; J E C Bromberg; M J B Taphoorn
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article     Date:  2005-08-20
Journal Detail:
Title:  Neuroradiology     Volume:  47     ISSN:  0028-3940     ISO Abbreviation:  Neuroradiology     Publication Date:  2005 Dec 
Date Detail:
Created Date:  2005-12-01     Completed Date:  2006-03-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1302751     Medline TA:  Neuroradiology     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  887-91     Citation Subset:  IM    
Department of Neurology, University Medical Center Utrecht, The Netherlands.
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MeSH Terms
Brain Neoplasms / pathology*
Contrast Media / administration & dosage
Disease Progression
Magnetic Resonance Imaging
Magnetic Resonance Spectroscopy*
Sensitivity and Specificity
Reg. No./Substance:
0/Contrast Media; 0/Protons

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