| Proton MRS imaging in the follow-up of patients with suspected low-grade gliomas. | |
| | |
MedLine Citation:
|
PMID: 16133483 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
We compared the value of changes in proton magnetic resonance spectroscopic imaging ((1)H-MRSI) with changes in clinical status and/or contrast-enhanced magnetic resonance imaging (MRI) in the monitoring of patients with suspected low-grade glioma (LGG). From June 1, 1999 till May 31, 2002, we included consecutive, neurologically intact adult patients suspected of having an LGG, demonstrating non-enhancing supratentorial lesions without edema or mass effect on MRI, and in whom all treatment (including a diagnostic biopsy) was deferred. Till January 1, 2003, patients were surveyed clinically and radiologically (contrast-enhanced MRI and (1)H-MRSI). Patients who showed progression on clinical examination and/or MRI were denoted as progressive disease. Other patients were denoted as stable disease. A decrease in NAA/CHO ratio of > or =20% compared to the baseline value was considered as indicative for progression on (1)H-MRSI. We included 14 patients with suspected LGG. Seven patients demonstrated progressive disease during the follow-up period, preceded or accompanied by concomitant (1)H-MRSI changes in five patients. Four of these five patients were operated on within the follow-up interval. The histological diagnosis demonstrated high-grade glioma in three and LGG in one patient. In the other two patients with progressive disease, no progression was found on (1)H-MRSI. The other seven patients demonstrated stable disease, but four of them showed progression on (1)H-MRSI. Our data do not show convincing evidence that (1)H-MRSI contributes to adequate monitoring and follow-up of patients with suspected LGG. Future research should preferably include pathological data at the time of (1)H-MRSI changes. |
| | |
Authors:
|
J C Reijneveld; J van der Grond; L M P Ramos; J E C Bromberg; M J B Taphoorn |
Related Documents
:
|
12117363 - Interrelationship of genetics and prenatal injury in the genesis of malformations of co... 8498843 - Amygdaloid sclerosis in temporal lobe epilepsy. 9327703 - Assessment of autonomic function at rest and during tilt testing in patients with vasov... |
Publication Detail:
|
Type: Clinical Trial; Comparative Study; Journal Article Date: 2005-08-20 |
Journal Detail:
|
Title: Neuroradiology Volume: 47 ISSN: 0028-3940 ISO Abbreviation: Neuroradiology Publication Date: 2005 Dec |
Date Detail:
|
Created Date: 2005-12-01 Completed Date: 2006-03-21 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 1302751 Medline TA: Neuroradiology Country: Germany |
Other Details:
|
Languages: eng Pagination: 887-91 Citation Subset: IM |
Affiliation:
|
Department of Neurology, University Medical Center Utrecht, The Netherlands. jc.reijneveld@vumc.nl |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Brain Neoplasms / pathology* Contrast Media / administration & dosage Disease Progression Female Humans Magnetic Resonance Imaging Magnetic Resonance Spectroscopy* Male Prognosis Protons Sensitivity and Specificity |
| Chemical | |
Reg. No./Substance:
|
0/Contrast Media; 0/Protons |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Percutaneous endoscopic cervical discectomy for discogenic cervical headache due to soft disc hernia...
Next Document: Effects of ionic and non-ionic paramagnetic contrast media on brain bio-electric activity.