| Proton MR spectroscopy and white matter hyperintensities in idiopathic normal pressure hydrocephalus and other dementias. | |
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MedLine Citation:
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PMID: 20647518 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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The differentiation of idiopathic normal-pressure hydrocephalus (INPH) from other types of dementia is a clinical challenge. The aim of this prospective study was to evaluate the role of proton MR spectroscopy (MRS) and white matter hyperintensities (WMH) in the diagnosis of INPH, predicting response to therapy and differentiating INPH from other dementias. The study included 18 patients with INPH (Group 1), 11 patients with other types of dementia (Group 2) and 20 control patients (Group 3). The value of WMH scores and MRS findings in diagnosis, evaluation of response to therapy and in the differentiation of INPH from other dementias was statistically evaluated. The level of statistical significance was set at p<0.05 (Kruskal-Wallis and Mann-Whitney U-test). In both Groups 1 and 2, N-acetylaspartate (NAA)/choline-NAA/creatine ratios were significantly less than in the control group (p<0.05). The WMH and MRS findings of Groups 1 and 2 demonstrated no statistically significant correlation (p>0.05). No correlation was found between the outcome of shunt operations and WMH and MRS findings (p>0.05). In conclusion, neither WMH nor MRS were useful in differentiating INPH from other types of dementia. WMH and MRS showed no additional benefit in identifying INPH patients who will better respond to shunt therapy. |
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Authors:
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O Algin; B Hakyemez; M Parlak |
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Publication Detail:
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Type: Journal Article Date: 2010-07-20 |
Journal Detail:
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Title: The British journal of radiology Volume: 83 ISSN: 1748-880X ISO Abbreviation: Br J Radiol Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-08-26 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0373125 Medline TA: Br J Radiol Country: England |
Other Details:
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Languages: eng Pagination: 747-52 Citation Subset: AIM; IM |
Affiliation:
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Atatürk Training and Education Hospital, Radiology Department, Ankara, Turkey. droktayalgin@gmail.com |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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