Document Detail

Proton MR spectroscopy of metabolite concentrations in temporal lobe epilepsy and effect of temporal lobe resection.
MedLine Citation:
PMID:  19118980     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To use proton Magnetic Resonance Spectroscopy (MRS) to measure in vivo temporal lobe GABA and glutamate plus glutamine (GLX) concentrations in patients with temporal lobe epilepsy (TLE) attributable to unilateral hippocampal sclerosis (HS) before and following anterior temporal lobe resection (ATLR).
METHODS: We obtained quantitative short echo time MRS in both temporal lobes of 15 controls and 16 patients with TLE and HS, and repeat spectra in 10 patients after ATLR. We measured the concentrations of N-acetyl aspartate+N-acetyl aspartyl-glutamate (NAAt), creatine plus phosphocreatine (Cr), and glutamate+glutamine (GLX) using a metabolite-nulled sequence designed to minimize macromolecule artifact. GABA concentrations were measured using a previously described double quantum filter.
RESULTS: In patients with TLE, NAAt/Cr was reduced in ipsilateral and contralateral temporal lobes. No significant variation in GLX/Cr or GABA+/Cr was evident in any group although GABA+/Cr was highest in the ipsilateral temporal lobe in TLE. After ATLR there was a trend to normalization of NAAt/Cr in the contralateral temporal lobe but no change in individual metabolite concentrations, GLX/Cr or GABA+/Cr compared to pre-surgery levels.
DISCUSSION: Temporal lobe epilepsy was associated with bilateral reduction in NAAt/Cr but not significant abnormality in GABA+/Cr or GLX/Cr. Normalization of NAAt/Cr in the contralateral temporal lobe was seen following successful ATLR.
Robert J Simister; Mary A McLean; Gareth J Barker; John S Duncan
Publication Detail:
Type:  Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-12-31
Journal Detail:
Title:  Epilepsy research     Volume:  83     ISSN:  1872-6844     ISO Abbreviation:  Epilepsy Res.     Publication Date:  2009 Feb 
Date Detail:
Created Date:  2009-02-03     Completed Date:  2009-06-22     Revised Date:  2014-02-19    
Medline Journal Info:
Nlm Unique ID:  8703089     Medline TA:  Epilepsy Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  168-76     Citation Subset:  IM    
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MeSH Terms
Aspartic Acid / analogs & derivatives,  metabolism
Brain Chemistry / physiology*
Brain Mapping
Carnosine / analogs & derivatives,  metabolism
Creatine / metabolism
Epilepsy, Temporal Lobe / metabolism*,  surgery*
Glutamic Acid / metabolism
Magnetic Resonance Imaging / methods
Magnetic Resonance Spectroscopy / methods*
Middle Aged
Protons / diagnostic use*
Young Adult
gamma-Aminobutyric Acid / metabolism
Grant Support
G9805989//Medical Research Council; //Medical Research Council
Reg. No./Substance:
0/Protons; 30KYC7MIAI/Aspartic Acid; 3650-73-5/homocarnosine; 3KX376GY7L/Glutamic Acid; 56-12-2/gamma-Aminobutyric Acid; 8HO6PVN24W/Carnosine; 997-55-7/N-acetylaspartate; MU72812GK0/Creatine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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