Document Detail


Protocetraric acid: an excellent broad spectrum compound from the lichen Usnea albopunctata against medically important microbes.
MedLine Citation:
PMID:  25174415     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The aim of this study was to investigate the antimicrobial property of the compounds present in the lichen Usnea albopunctata. Ethyl acetate extract of the lichen was purified by column chromatography to yield a major compound which was characterised by spectroscopic methods as protocetraric acid. In this study, protocetraric acid recorded significant broad spectrum antimicrobial property against medically important human pathogenic microbes. The prominent antibacterial activity was recorded against Salmonella typhi (0.5 μg/mL). Significant antifungal activity was recorded against Trichophyton rubrum (1 μg/mL), which is significantly better that the standard antifungal agent. Protocetraric acid is reported here for the first time from U. albopunctata. Thus the results of this study suggest that protocetraric acid has significant antimicrobial activities and has a strong potential to be developed as an antimicrobial drug against pathogenic microbes.
Authors:
Kumar S Nishanth; R S Sreerag; I Deepa; C Mohandas; Bala Nambisan
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-8-30
Journal Detail:
Title:  Natural product research     Volume:  -     ISSN:  1478-6427     ISO Abbreviation:  Nat. Prod. Res.     Publication Date:  2014 Aug 
Date Detail:
Created Date:  2014-9-1     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101167924     Medline TA:  Nat Prod Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  1-4     Citation Subset:  -    
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