Document Detail


Prothymosin alpha: in search of a function.
MedLine Citation:
PMID:  8535184     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Prothymosin alpha is an acidic nuclear protein that is expressed at high levels in a wide variety of cell types. Accumulating data correlate prothymosin expression with alterations in the proliferative state of cells. Some data indicates that prothymosin may actually be necessary, if not sufficient, for proliferation, and that prothymosin may function in a c-myc associated pathway. Prothymosin is highly conserved through evolution suggesting a key function, however, that function remains unknown.
Authors:
M R Smith
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Leukemia & lymphoma     Volume:  18     ISSN:  1042-8194     ISO Abbreviation:  Leuk. Lymphoma     Publication Date:  1995 Jul 
Date Detail:
Created Date:  1996-02-07     Completed Date:  1996-02-07     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  9007422     Medline TA:  Leuk Lymphoma     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  209-14     Citation Subset:  IM    
Affiliation:
Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Differentiation / physiology
Cell Division / physiology
Hematopoietic Stem Cells / physiology
Humans
Multigene Family
Nuclear Proteins / physiology*
Protein Precursors / genetics,  physiology*
Protein Processing, Post-Translational
Thymosin / analogs & derivatives*,  genetics,  physiology
Chemical
Reg. No./Substance:
0/Nuclear Proteins; 0/Protein Precursors; 0/prothymosin alpha; 0/thymalfasin; 61512-21-8/Thymosin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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