Document Detail

Prothymosin alpha: in search of a function.
MedLine Citation:
PMID:  8535184     Owner:  NLM     Status:  MEDLINE    
Prothymosin alpha is an acidic nuclear protein that is expressed at high levels in a wide variety of cell types. Accumulating data correlate prothymosin expression with alterations in the proliferative state of cells. Some data indicates that prothymosin may actually be necessary, if not sufficient, for proliferation, and that prothymosin may function in a c-myc associated pathway. Prothymosin is highly conserved through evolution suggesting a key function, however, that function remains unknown.
M R Smith
Related Documents :
8078674 - Secretion of a fibronectin-like substance from head and neck carcinomas.
17460414 - Modulation of epstein-barr virus latent membrane protein 1 activity by intrabodies.
6206304 - Expression of intermediate filaments in established human lung cancer cell lines. an in...
7915034 - Distribution of proliferating-cell nuclear antigen and epidermal growth factor receptor...
21745194 - Camp signalling protects proximal tubular epithelial cells from cisplatin-induced apopt...
24670214 - Colonizing while migrating: how do individual enteric neural crest cells behave?
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Leukemia & lymphoma     Volume:  18     ISSN:  1042-8194     ISO Abbreviation:  Leuk. Lymphoma     Publication Date:  1995 Jul 
Date Detail:
Created Date:  1996-02-07     Completed Date:  1996-02-07     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  9007422     Medline TA:  Leuk Lymphoma     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  209-14     Citation Subset:  IM    
Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Cell Differentiation / physiology
Cell Division / physiology
Hematopoietic Stem Cells / physiology
Multigene Family
Nuclear Proteins / physiology*
Protein Precursors / genetics,  physiology*
Protein Processing, Post-Translational
Thymosin / analogs & derivatives*,  genetics,  physiology
Reg. No./Substance:
0/Nuclear Proteins; 0/Protein Precursors; 0/prothymosin alpha; 0/thymalfasin; 61512-21-8/Thymosin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Regulation of cell-matrix adhesion by receptor tyrosine kinases.
Next Document:  Interferon-gamma in multiple myeloma.