Document Detail


Prothrombotic state and impaired fibrinolysis in bullous pemphigoid, the most frequent autoimmune blistering disease.
MedLine Citation:
PMID:  23199326     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Bullous pemphigoid (BP) is a potentially life-threatening autoimmune blistering disease that is burdened with an increased risk of cardiovascular events. In BP, there is an interplay between inflammation and coagulation both locally, which contributes to skin damage, and systemically, which leads to a prothrombotic state. Fibrinolysis is an important defence mechanism against thrombosis, but has only been studied locally in BP and no systemic data are available. The aim of this observational study was to evaluate systemic fibrinolysis and coagulation activation in patients with BP. We measured parameters of fibrinolysis and coagulation by immunoenzymatic methods in plasma from 20 patients with BP in an active phase and during remission after corticosteroid treatment. The controls were 20 age- and sex-matched healthy subjects. Plasma levels of plasminogen activator inhibitor type 1 (PAI-1) antigen, PAI-1 activity and tissue plasminogen activator (t-PA) antigen were significantly higher in the BP patients with active disease than in healthy controls (P = 0·0001 for all), as were the plasma levels of the fibrin fragment d-dimer and prothrombin fragment F1+2 (P = 0·0001 for both). During remission after treatment, levels of PAI-1 antigen and PAI-1 activity decreased significantly (P = 0·008 and P = 0·006, respectively), and there was also a significant decrease in plasma levels of d-dimer (P = 0·0001) and F1+2 (P = 0·0001). Fibrinolysis is inhibited in patients with active BP, due mainly to an increase in plasma levels of PAI-1. Corticosteroids not only induce the regression of BP lesions, but also reduce the inhibition of fibrinolysis, which may contribute to decreasing thrombotic risk.
Authors:
A V Marzano; A Tedeschi; I Polloni; C Crosti; M Cugno
Related Documents :
24254696 - Reliability of the icp-aes for trace elements studies of biological materials.
24431286 - Brief report: spuriously low serum igg4 concentrations caused by the prozone phenomenon...
23226566 - Interactions between serum vitamin d levels and vitamin d receptor gene foki polymorphi...
1333776 - The second international standard for anti-poliovirus sera types 1, 2 and 3.
21804276 - Elevated plasma levels of adropin in heart failure patients.
8674396 - Biochemical effects of oral sodium phosphate.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical and experimental immunology     Volume:  171     ISSN:  1365-2249     ISO Abbreviation:  Clin. Exp. Immunol.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2012-12-03     Completed Date:  2013-02-19     Revised Date:  2014-01-10    
Medline Journal Info:
Nlm Unique ID:  0057202     Medline TA:  Clin Exp Immunol     Country:  England    
Other Details:
Languages:  eng     Pagination:  76-81     Citation Subset:  IM    
Copyright Information:
© 2012 British Society for Immunology.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adrenal Cortex Hormones / therapeutic use
Aged
Aged, 80 and over
Autoimmunity*
Blood Coagulation / drug effects,  immunology*
Female
Fibrin Fibrinogen Degradation Products / analysis
Fibrinolysis / drug effects,  immunology*
Humans
Male
Middle Aged
Pemphigoid, Bullous / blood,  drug therapy,  immunology*
Peptide Fragments / blood
Plasminogen Activator Inhibitor 1 / blood
Protein Precursors / blood
Prothrombin
Thrombosis / blood,  drug therapy,  prevention & control
Tissue Plasminogen Activator / blood
Chemical
Reg. No./Substance:
0/Adrenal Cortex Hormones; 0/Fibrin Fibrinogen Degradation Products; 0/Peptide Fragments; 0/Plasminogen Activator Inhibitor 1; 0/Protein Precursors; 0/fibrin fragment D; 72270-84-9/prothrombin fragment 1; 78768-79-3/prothrombin fragment 2; 9001-26-7/Prothrombin; EC 3.4.21.68/Tissue Plasminogen Activator
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Intestinal anti-tissue transglutaminase antibodies in potential coeliac disease.
Next Document:  Screening for insulinoma antigen 2 and zinc transporter 8 autoantibodies: a cost-effective and age-i...