Document Detail

Prothrombotic disorders and abnormal neurodevelopmental outcome in infants with neonatal cerebral infarction.
MedLine Citation:
PMID:  11389264     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND PURPOSE: The aim of this study was to evaluate the occurrence of prothrombotic disorders in a well-characterized cohort of infants with neonatal stroke and to document any association of prothrombotic disorders with the type of infarct seen on magnetic resonance imaging (MRI) and clinical outcome. METHODS: Twenty-four infants with perinatal cerebral infarction confirmed by neonatal MRI were enrolled in the study. All the infants and, when possible, both parents were tested to identify inherited and acquired prothrombotic disorders. RESULTS: None of the infants had a significant bleeding diathesis, but 10 (42%) had at least 1 prothrombotic risk factor. Five children showed heterozygosity for factor V Leiden, and 6 had high factor VIIIc concentrations. There was a striking association between the occurrence of these abnormalities and both the presence of cerebral hemorrhage on MRI and poor neurologic outcome. Eight of the 11 patients (73%) with hemiplegia or global developmental delay had factor V Leiden and/or raised factor VIIIc, whereas only 1 of the 13 patients (8%) with normal outcome had any prothrombotic risk factors. In particular, all 5 infants with factor V Leiden had hemiplegia, compared with only 4 of the 19 infants without factor V Leiden (21%). CONCLUSIONS: These data suggest that the presence of prothrombotic risk factors and, in particular, of the factor V Leiden mutation, is significantly associated with poor outcome after perinatal cerebral infarction.
E Mercuri; F Cowan; G Gupte; R Manning; M Laffan; M Rutherford; A D Edwards; L Dubowitz; I Roberts
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pediatrics     Volume:  107     ISSN:  1098-4275     ISO Abbreviation:  Pediatrics     Publication Date:  2001 Jun 
Date Detail:
Created Date:  2001-06-04     Completed Date:  2001-08-30     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0376422     Medline TA:  Pediatrics     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1400-4     Citation Subset:  AIM; IM    
Departments of Paediatrics, Imperial College, Hammersmith Campus, London, United Kingdom.
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MeSH Terms
Activated Protein C Resistance / blood*,  epidemiology
Cerebral Infarction / blood,  diagnosis*,  epidemiology
Developmental Disabilities / blood,  diagnosis*,  epidemiology
Factor V / analysis,  genetics
Factor VIII / analysis,  genetics
Infant, Newborn
Magnetic Resonance Imaging / statistics & numerical data
Nervous System Diseases / blood,  diagnosis*,  epidemiology
Risk Factors
Thrombophilia / blood,  diagnosis*,  genetics
Reg. No./Substance:
0/factor V Leiden; 9001-24-5/Factor V; 9001-27-8/Factor VIII

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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