Document Detail

Prothrombin fragment 1.2 in both treated and untreated hypertensive patients.
MedLine Citation:
PMID:  8302396     Owner:  NLM     Status:  MEDLINE    
The coagulation parameters factor VII, fibrin monomers, thrombin-antithrombin III (TAT) complexes and fragment 1.2 (F 1.2) were studied in 43 treated and 11 untreated patients (27 males, 27 females age range 19-70 years) with hypertension of moderate severity. The patients included in this study who were treated with antihypertensive drugs were still hypertensive in spite of their treatment. The median F 1.2 concentrations (interquartile range) in the hypertensive patients were more than double those of the reference group: 1.47 (0.79) nmol/l as against 0.74 (0.49) nmol/l (p < 0.0001). Median concentrations of TAT complexes 2.9 (1.7) micrograms/l versus 2.6 (1.6) micrograms/l (p < 0.02) as well as those of fibrin monomers 14.2 (4.6) nmol/l as against 10.6 (2.0) nmol/l (p < 0.01) also were significantly elevated in the hypertensive patients, but to a lesser extent. For factor VII a significant difference was found between males and females. The median factor VII value in the male patients was 137% (32%) compared with 100% (33%) in the male reference group (p < 0.001). In the hypertensive female patients this median value was 147% (36%) in comparison with 139% (60%) in the female reference group (p < 0.01). By the Spearman rank test, no correlations were found between the coagulation parameters and systolic or diastolic blood pressure, age or duration of hypertension. F 1.2 values were correlated with fibrin monomers (r = 0.33, p < 0.03) but not with the other coagulation parameters studied. The elevated F 1.2 values, together with elevated concentrations of TAT complexes and fibrin monomers, are signs of an activated coagulation system in these hypertensive patients.
S H Donders; F A Lustermans; J W van Wersch
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Netherlands journal of medicine     Volume:  43     ISSN:  0300-2977     ISO Abbreviation:  Neth J Med     Publication Date:  1993 Oct 
Date Detail:
Created Date:  1994-03-10     Completed Date:  1994-03-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0356133     Medline TA:  Neth J Med     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  174-8     Citation Subset:  IM    
Department of Internal Medicine, De Wever Hospital, Heerlen, Netherlands.
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MeSH Terms
Antihypertensive Agents / therapeutic use*
Antithrombin III / chemistry
Factor VII / chemistry
Fibrin Fibrinogen Degradation Products / chemistry
Hypertension / blood*,  drug therapy*
Middle Aged
Peptide Fragments / chemistry*
Peptide Hydrolases / chemistry
Prothrombin / chemistry*
Severity of Illness Index
Sex Characteristics
Reg. No./Substance:
0/Antihypertensive Agents; 0/Fibrin Fibrinogen Degradation Products; 0/Peptide Fragments; 0/antithrombin III-protease complex; 0/fibrinmonomer; 0/prothrombin fragment 1.2; 9000-94-6/Antithrombin III; 9001-25-6/Factor VII; 9001-26-7/Prothrombin; EC 3.4.-/Peptide Hydrolases

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