| Prothrombin complex concentrate (Beriplex P/N) for control of bleeding after kidney trauma in a rabbit dilutional coagulopathy model. | |
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MedLine Citation:
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PMID: 19913880 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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INTRODUCTION: Fluid resuscitation after trauma often results in dilutional coagulopathy that may hinder control of bleeding and, once initial hemostasis has been secured, heighten risk of perioperative bleeding when further surgery is required. Since multiple coagulation factor deficiencies typically accompany fluid resuscitation, prothrombin complex concentrate (PCC) containing factors II, VII, IX and X may potentially offer greater hemostatic efficacy than coagulation factor monotherapy. MATERIALS AND METHODS: Anesthetized normothermic rabbits were hemodiluted 50-60% by phased blood withdrawal and infusion of hydroxyethyl starch and erythrocytes. The animals were randomly assigned to receive saline placebo, 25 IU x kg(-1) PCC (Beriplex P/N) or 180 microg x kg(-1) activated recombinant factor VII (rFVIIa; NovoSeven). Immediately thereafter, bleeding was precipitated by a standardized kidney incision. RESULTS: PCC accelerated hemostasis compared both with saline and rFVIIa (p=0.002 for both comparisons). The median times to hemostasis in the PCC, saline and rFVIIa groups were 12, 19 and 28 min, respectively. PCC reduced blood loss by a median of 43 mL with a 95% confidence interval (CI) of 8.0-67.5 mL vs. saline and 82 mL (CI, 35.0-110.0 mL) vs. rFVIIa. PCC augmented peak thrombin generation by a median of 104.1 nM (CI, 78.3-142.3 nM) compared with saline and 105.8 nM (CI, 70.7-139.5 nM ) relative to rFVIIa. At the respective 180 microg x kg(-1) and 25 IU x kg(-1) doses tested, rFVIIa displayed thrombogenicity in the Wessler stasis model, while PCC did not. CONCLUSIONS: In an animal model of dilutional coagulopathy and kidney trauma, PCC accelerated hemostasis and diminished blood loss compared with rFVIIa monotherapy. |
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Authors:
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Ingo Pragst; Franz Kaspereit; B?rbel D?rr; Gerhard Dickneite |
Publication Detail:
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Type: Journal Article Date: 2009-11-14 |
Journal Detail:
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Title: Thrombosis research Volume: 125 ISSN: 1879-2472 ISO Abbreviation: Thromb. Res. Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-03-01 Completed Date: 2010-07-01 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0326377 Medline TA: Thromb Res Country: United States |
Other Details:
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Languages: eng Pagination: 272-7 Citation Subset: IM |
Copyright Information:
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(c) 2009 Elsevier Ltd. All rights reserved. |
Affiliation:
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Department of Pharmacology and Toxicology, CSL Behring GmbH, Marburg, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Coagulation Disorders / etiology, therapy* Blood Coagulation Factors / therapeutic use* Disease Models, Animal Female Hemodilution / methods Hemorrhage / etiology, therapy* Hemostasis Kidney / injuries* Prothrombin Time Rabbits Random Allocation Wounds and Injuries / therapy* |
| Chemical | |
Reg. No./Substance:
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0/Blood Coagulation Factors; 37224-63-8/prothrombin complex concentrates |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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