Document Detail

Prothrombin 20210 G/A defect as a cause of mesenteric venous infarction: report of a case.
MedLine Citation:
PMID:  17342369     Owner:  NLM     Status:  MEDLINE    
A 50-year-old man with abdominal pain, nausea, and vomiting presented at our emergency department. Physical examination revealed diffuse abdominal tenderness and absent bowel sounds. Computed tomography showed partial portal vein thrombosis extending to the right portal vein and the superior mesenteric vein, perfusion defects in the liver, and nonopacified intestinal segment after contrast injection. An emergency laparotomy was performed. The wall of the distal jejunum was edematous, congested, and a 10-cm jejunal segment was necrotic. A partial intestinal resection and a primary anastomosis were performed. Screening for thrombophilia revealed a heterozygote 20210 G/A mutation of the prothrombin gene. Anticoagulation was initiated. Computed tomography 45 days after surgery showed a complete dissolution of the thrombi and cavernous transformation in the main portal vein. His subsequent clinical course was uneventful. Mesenteric venous thrombosis which causes an intestinal infarction is rare, and also difficult to diagnose. However, a prothrombin 20210 defect should be considered in the differential diagnosis of patients with unexplained thrombosis.
Erdal Karagulle; Emin Turk; Huseyin Savas Gokturk; Erkan Yildirim; Gokhan Moray
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2007-03-09
Journal Detail:
Title:  Surgery today     Volume:  37     ISSN:  0941-1291     ISO Abbreviation:  Surg. Today     Publication Date:  2007  
Date Detail:
Created Date:  2007-03-07     Completed Date:  2007-10-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9204360     Medline TA:  Surg Today     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  251-3     Citation Subset:  IM    
Department of General Surgery, Baskent University, Hocacihan mah. Saray caddesi No:1, Selcuklu, Konya 42080, Turkey.
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MeSH Terms
Anticoagulants / therapeutic use
Ischemia / etiology*,  surgery
Jejunal Diseases / etiology*,  surgery
Jejunum / blood supply*,  pathology
Mesenteric Veins*
Middle Aged
Portal Vein
Prothrombin / genetics*
Venous Thrombosis / complications,  drug therapy,  genetics*
Reg. No./Substance:
0/Anticoagulants; 9001-26-7/Prothrombin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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