Document Detail


Proteomics in antiphospholipid syndrome: a review.
MedLine Citation:
PMID:  20353974     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The presence of antiphospholipid antibodies (aPL) has been closely related to the development of thrombosis and complications in pregnancy. However, not all patients with aPL will develop those clinical features. The exact pathogenic mechanisms leading to thrombosis and/or pregnancy morbidity are poorly understood. Currently, biomarkers which enable one to predict the prognosis of patients with positive aPL are not readily available. Current advances in genomics and proteomics provide the opportunity to discover novel biomarkers based on changes in concentration levels or post-translational modifications of proteins and peptides. These techniques are now being applied in various areas of medicine with very promising results. This review covers recent studies that have used this approach for a better understanding of the pathogenic mechanisms involved in the development of thrombosis in patients with antiphospholipid syndrome (APS). Although, there are very few qualified biomarkers that have arisen as a result of efforts in proteomics, it is expected that these techniques will deliver biomarkers that might ultimately identify different subgroups of APS patients with various prognoses that might have implications with respect to management and prognosis.
Authors:
M J Cuadrado; M A Aguirre; N Barbarroja; M A Khamashta; Ch Lopez-Pedrera
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Lupus     Volume:  19     ISSN:  1477-0962     ISO Abbreviation:  Lupus     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-03-31     Completed Date:  2010-06-30     Revised Date:  2010-09-01    
Medline Journal Info:
Nlm Unique ID:  9204265     Medline TA:  Lupus     Country:  England    
Other Details:
Languages:  eng     Pagination:  385-8     Citation Subset:  IM    
Affiliation:
Lupus Research Unit, St Thomas' Hospital, London, UK. mjcuadrado@yahoo.com
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MeSH Terms
Descriptor/Qualifier:
Animals
Antibodies, Antiphospholipid / immunology*
Antiphospholipid Syndrome / complications,  immunology*,  physiopathology
Biological Markers / metabolism
Female
Humans
Pregnancy
Pregnancy Complications / immunology
Prognosis
Proteomics*
Thrombosis / etiology,  physiopathology
Chemical
Reg. No./Substance:
0/Antibodies, Antiphospholipid; 0/Biological Markers

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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