Document Detail


Proteomics for the elucidation of cold adaptation mechanisms in Listeria monocytogenes.
MedLine Citation:
PMID:  20620249     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Listeria monocytogenes, one of the major food-related pathogens, is the aetiological agent of listeriosis, a potentially life-threatening illness. It is able to survive in hostile environments and stress conditions such as those encountered in food-processing technologies (high salt concentration, wide range of pH and temperature, low water availability) and it also thrives at temperatures ranging from -0.4 to 45 °C. In this study, expression proteomics was applied to gain insight into key cellular events that allow L. monocytogenes to survive and multiply even at refrigeration temperatures. Interestingly, we observed that the adaptation processes mainly affect biochemical pathways related to protein synthesis and folding, nutrient uptake and oxidative stress. Furthermore, proteins implicated in metabolic pathways for energy production, such as glycolysis and Pta-AckA pathway, were present to a higher level in the cells grown at 4 °C. This suggests that, on the whole, cells exhibit an enhanced demand for energy to sustain cold growth. Proteomics may represent a key tool in deciphering specific mechanisms underlying cold adaptation response and, more widely, cell machinery.
Authors:
Giuseppina Cacace; Maria F Mazzeo; Alida Sorrentino; Valentina Spada; Antonio Malorni; Rosa A Siciliano
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-07-08
Journal Detail:
Title:  Journal of proteomics     Volume:  73     ISSN:  1876-7737     ISO Abbreviation:  J Proteomics     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-09-13     Completed Date:  2011-01-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101475056     Medline TA:  J Proteomics     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  2021-30     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier B.V. All rights reserved.
Affiliation:
Proteomic and Biomolecular Mass Spectrometry Center, Institute of Food Science, CNR, Avellino, Italy.
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MeSH Terms
Descriptor/Qualifier:
Adaptation, Physiological*
Cold Temperature*
Gene Expression Profiling
Listeria monocytogenes / genetics,  physiology*
Metabolic Networks and Pathways / genetics
Protein Folding
Proteomics

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