Document Detail


Proteomics of acute coronary syndromes.
MedLine Citation:
PMID:  19361350     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Acute coronary syndromes (ACS), such as unstable angina, acute myocardial infarction, and sudden cardiac death, are commonly associated with the presence of vulnerable plaques in coronary arteries. Rupture or erosion of vulnerable plaques results in the formation of luminal thrombi due to the physical contact between platelets and thrombogenic elements within the atherosclerotic lesions. Considering the socioeconomic burden of ACS, it is imperative that the scientific community achieves a clear understanding of the multifaceted pathophysiology of vulnerable atheroma to identify accurate prognostic biomarkers and therapeutic targets. The analytical power of modern proteomic technologies could facilitate our understanding of vulnerable plaques and lead to the discovery of novel therapeutic targets and diagnostic biomarkers.
Authors:
Athanasios Didangelos; David Simper; Claudia Monaco; Manuel Mayr
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Current atherosclerosis reports     Volume:  11     ISSN:  1534-6242     ISO Abbreviation:  Curr Atheroscler Rep     Publication Date:  2009 May 
Date Detail:
Created Date:  2009-04-13     Completed Date:  2009-08-06     Revised Date:  2014-02-19    
Medline Journal Info:
Nlm Unique ID:  100897685     Medline TA:  Curr Atheroscler Rep     Country:  United States    
Other Details:
Languages:  eng     Pagination:  188-95     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Acute Coronary Syndrome / physiopathology*
Coronary Thrombosis / physiopathology*
Humans
Proteomics*
Grant Support
ID/Acronym/Agency:
FS/08/002/24537//British Heart Foundation; //British Heart Foundation

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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