Document Detail

Proteomic technologies for prenatal diagnostics: advances and challenges ahead.
MedLine Citation:
PMID:  19210129     Owner:  NLM     Status:  MEDLINE    
Proteomics-based identification of biomarkers for fetal abnormalities in maternal plasma, amniotic fluid and reproductive fluids has made significant progress in the past 5 years. This is attributed mainly to advances in various technology platforms associated with mass spectrometry-based techniques. As these techniques are highly sensitive and require only small quantities of body fluids, it is hoped that they will pave the way for the development of effective noninvasive approaches, without subjecting the developing fetus to the same degree of harm as current invasive procedures (e.g., amniocentesis). It is possible that these developments will include same-day analyses, thereby permitting rapid intervention when necessary. To date, a host of body fluids, such as maternal serum and plasma, amniotic fluid, cervical fluid, vaginal fluid, urine, saliva or fetal material, such as placental trophoblast, fetal membranes or cord blood, have been used successfully in the quest to develop markers for a number of pregnancy-related pathologies. In the current review update we focus on the emergence of proteomics as a major platform technology in studying various types of fetal conditions and developing markers for pregnancy-related disorders, such fetal aneuploidy, preterm birth, preeclampsia, intra-amniotic infection and fetal stress. Should the development of these markers be successful, then it is to be envisaged that proteomic approaches will become standard of care for a number of disease conditions associated with feto-maternal health.
Mahesh Choolani; Kothandaraman Narasimhan; Varaprasad Kolla; Sinuhe Hahn
Related Documents :
3439439 - Amniotic immunoreactive trypsin in pregnancies with normal and pathological outcomes.
96249 - The placental transfer and materno-fetal disposition of methadone in monkeys.
48439 - Alpha fetoprotein levels in maternal serum and in amniotic fluid from early normal preg...
7738919 - Amnioinfusion.
10726689 - The effects of intraamniotic human neonatal urine and meconium on the intestines of the...
2261849 - Glucose and insulin concentration in amniotic fluid and in maternal blood in early and ...
11422409 - Haemorheological adaptation during pregnancy in a latin american population.
8147169 - Fetal macrosomia--pregnancy and delivery.
2042599 - Arias-stella reaction in fallopian tube epithelium. a light and electron microscopic st...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Expert review of proteomics     Volume:  6     ISSN:  1744-8387     ISO Abbreviation:  -     Publication Date:  2009 Feb 
Date Detail:
Created Date:  2009-02-12     Completed Date:  2009-06-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101223548     Medline TA:  Expert Rev Proteomics     Country:  England    
Other Details:
Languages:  eng     Pagination:  87-101     Citation Subset:  IM    
Diagnostic Biomarker Discovery Laboratory, Obstetrics and Gynaecology Department, National University Hospital, Singapore.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Biological Markers / analysis
Fetus / metabolism
Prenatal Diagnosis / methods*,  trends*
Proteomics / methods*,  trends*
Reg. No./Substance:
0/Biological Markers

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Bioanalytical tools for the discovery of eukaryotic glycoproteins applied to the analysis of bacteri...
Next Document:  An examination of attitudes, knowledge, and clinical practices among Pennsylvania pediatricians rega...