Document Detail


Proteomic strategies to elucidate pathogenic mechanisms of spirochetes.
MedLine Citation:
PMID:  21136767     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Spirochetes are a unique group of bacteria that include several motile and highly invasive pathogens that cause a multitude of acute and chronic disease processes. Nine genomes of spirochetes have been completed, which provide significant insights into pathogenic mechanisms of disease and reflect an often complex lifestyle associated with a wide range of environmental and host factors encountered during disease transmission and infection. Characterization of the outer membrane of spirochetes is of particular interest since it interacts directly with the host and environs during disease and likely contains candidate vaccinogens and diagnostics. In concert with appropriate fractionation techniques, the tools of proteomics have rapidly evolved to characterize the proteome of spirochetes. Of greater significance, studies have confirmed the differential expression of many proteins, including those of the outer membrane, in response to environmental signals encountered during disease transmission and infection. Characterization of the proteome in response to such signals provides novel insights to understand pathogenic mechanisms of spirochetes.
Authors:
Jarlath E Nally; Julian P Whitelegge; James A Carroll
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Publication Detail:
Type:  Journal Article     Date:  2007-08-07
Journal Detail:
Title:  Proteomics. Clinical applications     Volume:  1     ISSN:  1862-8346     ISO Abbreviation:  Proteomics Clin Appl     Publication Date:  2007 Sep 
Date Detail:
Created Date:  2010-12-07     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101298608     Medline TA:  Proteomics Clin Appl     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  1185-97     Citation Subset:  -    
Copyright Information:
Copyright © 2007 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Affiliation:
School of Agriculture, Food Science and Veterinary Medicine, University College Dublin, Ireland. jarlath.nally@ucd.ie.
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