| Proteomic modification by nitric oxide. | |
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MedLine Citation:
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PMID: 16891772 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The role of nitric oxide (NO) in cellular signaling has become one of the most rapidly growing areas in biology during the past two decades. As a gas and free radical with an unshared electron, nitric oxide participates in various biological processes. The interaction between NO and proteins may be roughly divided into two categories. In many instances, NO mediates its biological effects by activating guanylyl cyclase and elevates intracellular cyclic GMP synthesis from GTP. However, the list of cGMP-independent effects of NO is also growing at a rapid rate. In this review, the importance and relevance of nitrotyrosine formation are stressed. The utilization of intact cell cultures, tissues, and cell-free preparations along with the use of pharmacological, biochemical, and molecular biological approaches to characterize, purify, and reconstitute these NO regulatory pathways could lead to the development of new therapies for various pathological conditions that are characterized by unbalanced production of NO. |
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Authors:
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Ka Bian; Yan Ke; Yoshinori Kamisaki; Ferid Murad |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2006-08-05 |
Journal Detail:
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Title: Journal of pharmacological sciences Volume: 101 ISSN: 1347-8613 ISO Abbreviation: J. Pharmacol. Sci. Publication Date: 2006 Aug |
Date Detail:
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Created Date: 2006-08-21 Completed Date: 2006-10-03 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 101167001 Medline TA: J Pharmacol Sci Country: Japan |
Other Details:
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Languages: eng Pagination: 271-9 Citation Subset: IM |
Affiliation:
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The Institute of Molecular Medicine, The University of Texas-Houston Medical School, Houston, TX 77030, USA. ka.bian@uth.tmc.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cardiovascular System / metabolism, physiopathology Humans Hydrogen Peroxide / metabolism Models, Biological Nitric Oxide / metabolism, physiology* Proteome / metabolism* Signal Transduction / physiology |
| Chemical | |
Reg. No./Substance:
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0/Proteome; 10102-43-9/Nitric Oxide; 7722-84-1/Hydrogen Peroxide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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