Document Detail


Proteomic identification and profiling of canine lymphoma patients.
MedLine Citation:
PMID:  19453363     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study employed proteomic and bioinformatic approaches to identify serum biomarkers in canine lymphoma patients. Chilled serum samples derived from non-lymphoma (n = 92) and lymphoma (n = 87) patients were shipped from first opinion veterinary practices, subjected to ion exchange chromatography and analysed by surface-enhanced laser desorption ionization mass spectrometry. Nineteen serum protein peaks were identified between the two groups as being significantly different (P < 0.05) based upon their normalized ion intensities. Two biomarkers were identified that were capable of differentiating lymphoma and non-lymphoma patients. Analysis of the test data provided a positive predictive value (PPV) of 82%. A clinical follow-up study was carried out on 96 canine patients suspected of having lymphoma. Evaluation of this data gave a specificity value of 91%, sensitivity of 75%, PPV of 80% and negative predictive value of 88%. In conclusion, the expression pattern of two serum biomarkers has enabled serum samples to be classified into either lymphoma or non-lymphoma categories.
Authors:
L Ratcliffe; S Mian; K Slater; H King; M Napolitano; D Aucoin; A Mobasheri
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Veterinary and comparative oncology     Volume:  7     ISSN:  1476-5829     ISO Abbreviation:  Vet Comp Oncol     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-05-20     Completed Date:  2009-08-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101185242     Medline TA:  Vet Comp Oncol     Country:  England    
Other Details:
Languages:  eng     Pagination:  92-105     Citation Subset:  IM    
Affiliation:
PetScreen Ltd, BioCity, Nottingham, UK.
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MeSH Terms
Descriptor/Qualifier:
Age Factors
Animals
Blood Proteins / analysis*
Case-Control Studies
Diagnosis, Differential
Dog Diseases / blood*
Dogs
Lymphoma / blood,  veterinary*
Predictive Value of Tests
Proteomics*
Sensitivity and Specificity
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / veterinary*
Tumor Markers, Biological
Chemical
Reg. No./Substance:
0/Blood Proteins; 0/Tumor Markers, Biological

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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