Document Detail

Proteomic characterization of skin and epidermis in response to environmental agents.
MedLine Citation:
PMID:  16209658     Owner:  NLM     Status:  MEDLINE    
The skin and its outer epidermis layer in particular, prevent access of various environmental agents including potential allergens, irritants, carcinogens, ultraviolet radiation and microbes. Cells in the epidermis make a significant contribution to innate as well as adaptive immune reactions in skin. The skin immunity thus provides a biologic defense in response to hazardous environmental agents. Although proteomics has been utilized to establish skin proteomes and investigate skin responses to some environmental agents, it has not been extensively used to address the complexity of skin responses to various environments. This review summarizes cutaneous genes and proteins that have been characterized as related to skin exposure to environmental agents. In parallel, this review emphasizes functional proteomics and systems biology, which are believed to be an important future direction toward characterizing the skin proteome-environmental interaction and developing successful therapeutic strategies for skin diseases caused by environmental insults.
Chun-Ming Huang; Hui Xu; Chao-Cheng Wang; Craig A Elmets
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Expert review of proteomics     Volume:  2     ISSN:  1744-8387     ISO Abbreviation:  -     Publication Date:  2005 Oct 
Date Detail:
Created Date:  2005-10-07     Completed Date:  2006-12-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101223548     Medline TA:  Expert Rev Proteomics     Country:  England    
Other Details:
Languages:  eng     Pagination:  809-20     Citation Subset:  IM    
Department of Dermatology, Skin Diseases Research Center, University of Alabama, Birmingham, AL 35294-0019, USA.
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MeSH Terms
Environmental Exposure
Epidermis / drug effects*,  metabolism*
Gene Expression Profiling
Irritants / administration & dosage*,  pharmacology*
Skin / cytology,  drug effects*,  immunology,  metabolism*
Reg. No./Substance:

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