Document Detail

Proteomic biomarkers of intra-amniotic inflammation: relationship with funisitis and early-onset sepsis in the premature neonate.
MedLine Citation:
PMID:  17314690     Owner:  NLM     Status:  MEDLINE    
Our goal was to determine the relationship between 4 amniotic fluid (AF) proteomic biomarkers (human neutrophil defensins 2 and 1, calgranulins C and A) characteristic of intra-amniotic inflammation, and funisitis and early-onset sepsis in premature neonates. The mass restricted (MR) score was generated from AF obtained from women in preterm labor (n = 123). The MR score ranged from 0-4 (none to all biomarkers present). Funisitis was graded histologically and interpreted in relation to the MR scores. Neonates (n = 97) were evaluated for early-onset sepsis. There was significant correlation between the severity of AF inflammation and the presence (53/123) and grades of funisitis (p < 0.001). Funisitis occurred independently of the amniocentesis-to-delivery interval or status of the membranes and was best predicted by an MR score 3-4 and an earlier gestational age (GA) at delivery. Neonates born to women with an MR score 3-4 had an increased incidence of suspected/confirmed sepsis, even after adjusting for GA at birth. Calgranulin C had the highest association with clinically significant funisitis, while calgranulin A had the strongest association with early-onset sepsis. To conclude, AF proteomic analysis shows that women with MR scores 3-4 are more likely to have histologic funisitis, and deliver neonates with early-onset sepsis.
Catalin S Buhimschi; Irina A Buhimschi; Sonya Abdel-Razeq; Victor A Rosenberg; Stephen F Thung; Guomao Zhao; Erica Wang; Vineet Bhandari
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Pediatric research     Volume:  61     ISSN:  0031-3998     ISO Abbreviation:  Pediatr. Res.     Publication Date:  2007 Mar 
Date Detail:
Created Date:  2007-02-22     Completed Date:  2007-04-11     Revised Date:  2014-09-17    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  318-24     Citation Subset:  IM    
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MeSH Terms
Amniotic Fluid / metabolism*
Biological Markers / metabolism
Calgranulin A / metabolism
Chorioamnionitis / metabolism*,  pathology
Defensins / metabolism
Infant, Newborn
Infant, Premature
Prospective Studies
S100 Proteins / metabolism
Sepsis / complications,  metabolism*
Grant Support
K08 HL 074195/HL/NHLBI NIH HHS; K12 HD 047018/HD/NICHD NIH HHS; R01 HD 047321/HD/NICHD NIH HHS; R01 HD047321/HD/NICHD NIH HHS; R01 HD047321-01/HD/NICHD NIH HHS; R01 HD047321-02/HD/NICHD NIH HHS; R01 HD047321-03/HD/NICHD NIH HHS; R03 HD 50249/HD/NICHD NIH HHS
Reg. No./Substance:
0/Biological Markers; 0/Calgranulin A; 0/Defensins; 0/S100 Proteins; 0/S100A12 protein, human

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