| Proteomic biomarkers of intra-amniotic inflammation: relationship with funisitis and early-onset sepsis in the premature neonate. | |
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MedLine Citation:
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PMID: 17314690 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Our goal was to determine the relationship between 4 amniotic fluid (AF) proteomic biomarkers (human neutrophil defensins 2 and 1, calgranulins C and A) characteristic of intra-amniotic inflammation, and funisitis and early-onset sepsis in premature neonates. The mass restricted (MR) score was generated from AF obtained from women in preterm labor (n = 123). The MR score ranged from 0-4 (none to all biomarkers present). Funisitis was graded histologically and interpreted in relation to the MR scores. Neonates (n = 97) were evaluated for early-onset sepsis. There was significant correlation between the severity of AF inflammation and the presence (53/123) and grades of funisitis (p < 0.001). Funisitis occurred independently of the amniocentesis-to-delivery interval or status of the membranes and was best predicted by an MR score 3-4 and an earlier gestational age (GA) at delivery. Neonates born to women with an MR score 3-4 had an increased incidence of suspected/confirmed sepsis, even after adjusting for GA at birth. Calgranulin C had the highest association with clinically significant funisitis, while calgranulin A had the strongest association with early-onset sepsis. To conclude, AF proteomic analysis shows that women with MR scores 3-4 are more likely to have histologic funisitis, and deliver neonates with early-onset sepsis. |
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Authors:
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Catalin S Buhimschi; Irina A Buhimschi; Sonya Abdel-Razeq; Victor A Rosenberg; Stephen F Thung; Guomao Zhao; Erica Wang; Vineet Bhandari |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: Pediatric research Volume: 61 ISSN: 0031-3998 ISO Abbreviation: Pediatr. Res. Publication Date: 2007 Mar |
Date Detail:
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Created Date: 2007-02-22 Completed Date: 2007-04-11 Revised Date: 2013-04-08 |
Medline Journal Info:
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Nlm Unique ID: 0100714 Medline TA: Pediatr Res Country: United States |
Other Details:
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Languages: eng Pagination: 318-24 Citation Subset: IM |
Affiliation:
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Department of Obstetrics, Gynecology and Reproductive Sciences, Division of Perinatal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Amniotic Fluid / metabolism* Biological Markers / metabolism Calgranulin A / metabolism Chorioamnionitis / metabolism*, pathology Defensins / metabolism Female Humans Infant, Newborn Infant, Premature Male Pregnancy Prospective Studies Proteomics S100 Proteins / metabolism Sepsis / complications, metabolism* |
| Grant Support | |
ID/Acronym/Agency:
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K08 HL 074195/HL/NHLBI NIH HHS; K12 HD 047018/HD/NICHD NIH HHS; R01 HD 047321/HD/NICHD NIH HHS; R01 HD047321/HD/NICHD NIH HHS; R01 HD047321-01/HD/NICHD NIH HHS; R01 HD047321-02/HD/NICHD NIH HHS; R01 HD047321-03/HD/NICHD NIH HHS; R03 HD 50249/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Calgranulin A; 0/Defensins; 0/S100 Proteins; 0/S100A12 protein, human |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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