Document Detail


Proteomic biomarkers for diagnosis in acute myocardial infarction.
MedLine Citation:
PMID:  20923274     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Acute myocardial infarction (AMI) is considered the leading cause of morbidity and mortality in many industrialized nations. AMI is defined currently by detection of a rise and/or fall of cardiac biomarkers at least above the 99th percentile of the upper limit. Early detection of AMI could conceivably provide important information for understanding the molecular functions of heart disease, and would enable more effective diagnosis and treatment of patients. However, diagnostic approaches currently in use for the evaluation of patients, associated with chest pain or other symptoms suggestive of AMI are acceptable, but they are time-consuming, high-cost and labour-intensive in most cases. Thus, much work is needed in the development of biomarkers for accurate and cost-effective diagnosis of AMI and for effective management of patients. In this article, we give an overview of proteomic biomarkers for rapid and reliable diagnosis of AMI, focusing on biochemical characteristics and their clinical applications for point-of-care of AMI. We also postulate the future directions in the pursuit of integrated multiplex assay systems for multifunctional diagnosis in AMI.
Authors:
Jong Pil Park; Moon Ki Park; Jong Won Yun
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Publication Detail:
Type:  Journal Article     Date:  2010-10-05
Journal Detail:
Title:  Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals     Volume:  16     ISSN:  1366-5804     ISO Abbreviation:  Biomarkers     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-01-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9606000     Medline TA:  Biomarkers     Country:  England    
Other Details:
Languages:  eng     Pagination:  1-11     Citation Subset:  IM    
Affiliation:
Department of Herbal Pharmaceutical Engineering, Daegu Haany University, Gyeongsan, Gyeongbuk, Republic of Korea.
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