| Proteomic approaches to Sjögren's syndrome: a clue to interpret the pathophysiology and organ involvement of the disease. | |
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MedLine Citation:
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PMID:Â 20462525 Â Â Â Owner:Â NLM Â Â Â Status:Â MEDLINE Â Â Â |
Abstract/OtherAbstract:
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Sjögren's syndrome (SS) is a chronic, inflammatory, autoimmune disease characterized by lymphocytic infiltration of the exocrine glands leading to qualitatively altered and diminished or absent salivary and lachrymal secretion, and by marked B-cell hyperreactivity. Many efforts have been made to define a panel of salivary and lachrymal markers helpful to design diagnostic tests able to replace blood tests and tissue biopsies for the diagnosis of primary and secondary SS. Several proteomic-based studies have indicated that a number of proteins and peptides can be considered SS biomarkers, being 2-3-fold up- or down-regulated compared to normal subject or having an exclusive presence in the saliva or tears of SS patients. Unfortunately, several factors make it difficult to define a comprehensive salivary and lachrymal panel of markers of SS, as the lack of a comprehensive proteomic analysis of human tears and saliva of healthy subjects, the lack of uniform protocols to collect and treat these samples, and the high grade of posttranslational modification of the proteins in these fluids. |
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Authors:
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Gianfranco Ferraccioli; Maria De Santis; Giusy Peluso; Rosanna Inzitari; Chiara Fanali; Silvia Laura Bosello; Federica Iavarone; Massimo Castagnola |
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Publication Detail:
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Type: Journal Article; Review    Date: 2010-05-10 |
Journal Detail:
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Title: Autoimmunity reviews    Volume: 9    ISSN: 1873-0183    ISO Abbreviation: Autoimmun Rev    Publication Date: 2010 Jul |
Date Detail:
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Created Date:Â 2010-07-12 Â Â Â Completed Date:Â 2011-01-28 Â Â Â Revised Date:Â - Â Â Â |
Medline Journal Info:
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Nlm Unique ID: 101128967    Medline TA: Autoimmun Rev    Country: Netherlands    |
Other Details:
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Languages: eng    Pagination: 622-6    Citation Subset: IM    |
Affiliation:
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Department of Rheumatology - Institute of Internal Medicine and Geriatrics, Italy. gf.ferraccioli@rm.unicatt.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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B-Lymphocytes
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chemistry,Â
metabolism,Â
pathology Biological Markers / analysis* Humans Lacrimal Apparatus / chemistry*, metabolism Proteomics / methods* Saliva / chemistry, immunology Salivary Glands / chemistry*, metabolism Sjogren's Syndrome / diagnosis*, immunology, physiopathology Tears / chemistry, metabolism |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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