| Proteomic analysis of functional dyspepsia in stressed rats treated with traditional Chinese medicine "Wei Kangning". | |
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MedLine Citation:
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PMID: 21054522 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Background and Aim: Chinese traditional medical science is generally used as a therapeutic method against functional dyspepsia (FD) in China. Although great effort is made to understand the pharmaceutical mechanisms of Chinese traditional medicine, such as typical traditional Chinese medicine, Wei Kangning, there are still many mysteries to be uncovered. Methods: The model of FD was established by stimulating rats via tail damping and the rats were treated with traditional Chinese medicine, Wei Kangning. The proteins of the rat gastrointestinal tissues were extracted and run by 2-DE, then the differential proteins were identified using matrix-assisted laser desorption ionisation time-of-flight mass spectrometry and validated with Western blotting or fluorescent quantitation polymerase chain reaction. Results: A total of 228 unique proteins in FD model rats were detected with significant changes in their expression levels corresponding with traditional Chinese medicine, Wei Kangning, administration. Twenty-eight of these proteins were identified, which are involved in many biological functions, such as organism antioxidant enzymes, energy metabolism, glutathione S-transferase, pi2, superoxide dismutase 2 and alpha-enolase and so on. Conclusions: These proteomic results presented therefore provide additional support to the hypothesis that glutathione S-transferase, pi2, superoxide dismutase 2, α-enolase and voltage-dependent anion channel are the targets of FD treated with traditional Chinese medicine, Wei Kangning. |
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Authors:
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Wei Wei; Xia Li; Jianjun Hao; Rong Zhang; Jianli Guo; Yiqiang Zong; Yanjun Lu; Shen Qu; Jun Tian |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of gastroenterology and hepatology Volume: 26 ISSN: 1440-1746 ISO Abbreviation: J. Gastroenterol. Hepatol. Publication Date: 2011 Sep |
Date Detail:
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Created Date: 2011-09-02 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8607909 Medline TA: J Gastroenterol Hepatol Country: Australia |
Other Details:
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Languages: eng Pagination: 1425-33 Citation Subset: IM |
Copyright Information:
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© 2011 Journal of Gastroenterology and Hepatology Foundation and Blackwell Publishing Asia Pty Ltd. |
Affiliation:
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Digestion Department of Beijing Xuanwu Traditional Chinese Medical Hospital, Beijing, China Department of Biochemistry and Molecular Biology, Tongji Medical College, Hua Zhong University of Science and Technology, Wuhan, China Traditional Chinese Medicine Department of Wuhan Integrated TCM & Western Medicine Hospital, Wuhan, China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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