Document Detail


Proteomic analysis of salivary acidic proline-rich proteins in human preterm and at-term newborns.
MedLine Citation:
PMID:  17341109     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A 1 year follow-up investigation of salivary acidic proline-rich proteins (aPRPs) in preterm and at-term newborns using HPLC-ESI-IT-MS showed that (i) this class of proteins is constitutive rather than inducible, as it is still found in the oral cavity of preterm newborns from 180 days of postconception age (PCA); (ii) the expression of PRH-2 locus anticipates that of PRH-1, since Db isoforms are expressed some months after the PRP-1 and PRP-2 isoforms. The evaluation of the relative abundances of the different aPRPs isoforms and derivatives (differently phosphorylated and cleaved) as a function of PCA showed that (iii) the proteolytic enzymes generating truncated isoforms are also constitutive because they are fully active since 180 days of PCA; (iv) the kinase involved in aPRP phosphorylation is not fully mature in preterm newborns, but its activity increases with PCA, synchronizing with that of at-term newborns and reaching the adult levels at about 500-600 days of PCA, in concomitance with the beginning of deciduous dentition.
Authors:
Rosanna Inzitari; Giovanni Vento; Ettore Capoluongo; Simona Boccacci; Chiara Fanali; Tiziana Cabras; Costantino Romagnoli; Bruno Giardina; Irene Messana; Massimo Castagnola
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-03-07
Journal Detail:
Title:  Journal of proteome research     Volume:  6     ISSN:  1535-3893     ISO Abbreviation:  J. Proteome Res.     Publication Date:  2007 Apr 
Date Detail:
Created Date:  2007-04-09     Completed Date:  2007-07-24     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  101128775     Medline TA:  J Proteome Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1371-7     Citation Subset:  IM    
Affiliation:
Istituto di Biochimica e Biochimica Clinica, Istituto Scientifico Internazionale Paolo VI di ricerca sulla fertilità ed infertilità umana, Roma, Italy.
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MeSH Terms
Descriptor/Qualifier:
Chromatography, High Pressure Liquid
Humans
Infant, Newborn / metabolism*
Infant, Premature / metabolism*
Mouth / chemistry,  metabolism
Peptides / analysis*,  metabolism
Phosphorylation
Premature Birth
Proline-Rich Protein Domains
Protein Isoforms / analysis,  metabolism
Proteomics*
Saliva / chemistry,  metabolism
Salivary Proline-Rich Proteins
Salivary Proteins and Peptides / analysis*,  metabolism
Spectrometry, Mass, Electrospray Ionization
Chemical
Reg. No./Substance:
0/PRH1 protein, human; 0/Peptides; 0/Protein Isoforms; 0/Salivary Proline-Rich Proteins; 0/Salivary Proteins and Peptides

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