Document Detail

Proteomic analysis of amniotic fluid in pregnancies with Turner syndrome fetuses.
MedLine Citation:
PMID:  18363353     Owner:  NLM     Status:  MEDLINE    
Turner syndrome, occurring in 1:2500 female births, is caused by the complete or partial absence of one X chromosome. Amniotic fluid supernatant proteins from five second trimester pregnancies with Turner syndrome fetuses and five normal ones were analyzed by 2DE, MALDI-TOF-MS, and Western blot. Serotransferin, lumican, plasma retinol-binding protein, and apolipoprotein A-I were increased in Turner syndrome, while kininogen, prothrombin, and apolipoprotein A-IV were decreased. Since differentially expressed proteins are likely to cross the placenta barrier and be detected in maternal plasma, proteomic analysis may enhance research for noninvasive prenatal diagnosis of Turner syndrome.
Ariadni Mavrou; Athanasios K Anagnostopoulos; Aggeliki Kolialexi; Konstantinos Vougas; Nikos Papantoniou; Aris Antsaklis; Michael Fountoulakis; George Th Tsangaris
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-03-26
Journal Detail:
Title:  Journal of proteome research     Volume:  7     ISSN:  1535-3893     ISO Abbreviation:  J. Proteome Res.     Publication Date:  2008 May 
Date Detail:
Created Date:  2008-05-05     Completed Date:  2008-09-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101128775     Medline TA:  J Proteome Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1862-6     Citation Subset:  IM    
Medical Genetics, Athens University School of Medicine, Athens, Greece.
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MeSH Terms
Amniotic Fluid / chemistry*
Electrophoresis, Gel, Two-Dimensional
Fetus / physiology*
Molecular Sequence Data
Proteome / analysis*
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
Turner Syndrome / genetics,  metabolism*
Reg. No./Substance:

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