Document Detail


Proteome profile and biological activity of caprine, bovine and human milk fat globules.
MedLine Citation:
PMID:  22193558     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Upon combining bidimensional electrophoresis with monodimensional separation, a more comprehensive analysis of the milk fat globule membrane has been obtained. The proteomic profile of caprine milk fat globules revealed the presence of butyrophilin, lactadherin and perilipin as the major proteins, they were also associated to bovine and human milk fat globule membranes. Xanthine dehydrogenase/oxidase has been detected only in monodimensional gels. Biological activity of milk fat globules has been evaluated in Caco2-cells, as a representative model of the intestinal barrier. The increase of cell viability was indicative of a potential nutraceutical role for the whole milk fat globule, suggesting a possible employment in milk formula preparation.
Authors:
Stefano Spertino; Valentina Cipriani; Chiara De Angelis; Maria Gabriella Giuffrida; Francesco Marsano; Maria Cavaletto
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-12-21
Journal Detail:
Title:  Molecular bioSystems     Volume:  -     ISSN:  1742-2051     ISO Abbreviation:  -     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-12-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101251620     Medline TA:  Mol Biosyst     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Environmental and Life Sciences, University of Piemonte Orientale, Viale T. Michel, 11, 15121 Alessandria, Italy. maria.cavaletto@mfn.unipmn.it.
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