Document Detail

Proteome of brain glia: the molecular basis of diverse glial phenotypes.
MedLine Citation:
PMID:  24124134     Owner:  NLM     Status:  Publisher    
Several different types of non-neuronal glial cells with diverse phenotypes are present in the central nervous system (CNS), and all have distinct indispensible functions. Although glial cells primarily provide neurons with metabolic and structural support in the healthy brain, they may switch phenotype from a "resting" to a "reactive" state in response to pathological insults. Furthermore, this reactive gliosis is an invariant feature of the pathogeneses of CNS maladies. The glial proteome serves as a signature of glial phenotype, and not only executes physiological functions, but also acts as a molecular mediator of the reactive glial phenotype. The glial proteome is also involved in intra- and inter-cellular communications as exemplified by glia-glia and neuron-glia interactions. The utilization of authoritative proteomic tools and the bioinformatic analyses have helped to profile the brain glial proteome and explore the molecular mechanisms of diverse glial phenotypes. Furthermore, technologic innovations have equipped the field of "glioproteomics" with refined tools for studies of the expression, interaction, and function of glial proteins in the healthy and in the diseased CNS. Glioproteomics is expected to contribute to the elucidation of the molecular mechanisms of CNS pathophysiology and to the discovery of biomarkers and theragnostic targets in CNS disorders. This article is protected by copyright. All rights reserved.
Mithilesh Kumar Jha; Jae-Hong Kim; Kyuheum Jeon; Kyoungho Suk
Related Documents :
23658174 - Parvalbumin-containing chandelier and basket cell boutons have distinctive modes of mat...
23202314 - Conotoxins targeting neuronal voltage-gated sodium channel subtypes: potential analgesics?
24307404 - Novel dynein dync1h1 neck and motor domain mutations link distal sma and abnormal corti...
24906054 - Hybrid voltage sensor imaging of egfp-f expressing neurons in chicken midbrain slices.
25087644 - Abnormal white matter tractography of visual pathways detected by high-angular-resoluti...
17287354 - Queen pheromone modulates brain dopamine function in worker honey bees.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-10-9
Journal Detail:
Title:  Proteomics     Volume:  -     ISSN:  1615-9861     ISO Abbreviation:  Proteomics     Publication Date:  2013 Oct 
Date Detail:
Created Date:  2013-10-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101092707     Medline TA:  Proteomics     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
This article is protected by copyright. All rights reserved.
Department of Pharmacology, Brain Science & Engineering Institute, Kyungpook National University School of Medicine, Daegu, South Korea.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Do Individuals with and without Autism Spectrum Disorder Scan Faces Differently? A New Multi-Method ...
Next Document:  Synthesis of Highly Stable, Water-Dispersible Copper Nanoparticles as Catalysts for Nitrobenzene Red...