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Proteolytic processing is required for viral superantigen activity.
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MedLine Citation:
PMID:  7722465     Owner:  NLM     Status:  MEDLINE    
The mouse mammary tumor virus-7 superantigen (vSAG7) is proteolytically processed in B cells at as many as three positions. Proteolytic processing appears to be important for superantigen activity because a processed form of vSAG7 was predominant among those forms that were found to bind to major histocompatibility complex class II molecules. To determine the functional significance of proteolytic processing, a mutation was introduced in vSAG7 at one of the sites where proteolytic cleavage is thought to take place in B cells. Elimination of the putative processing site at position 171 abrogated detectable vSAG7 surface expression in B cells, indicating that proteolytic processing is required for vSAG7 function. Coexpression in insect cells of vSAG7 and furin, a proprotein-processing enzyme, also demonstrated that furin could process vSAG7 at position 171.
C G Park; M Y Jung; Y Choi; G M Winslow
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of experimental medicine     Volume:  181     ISSN:  0022-1007     ISO Abbreviation:  J. Exp. Med.     Publication Date:  1995 May 
Date Detail:
Created Date:  1995-05-25     Completed Date:  1995-05-25     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  2985109R     Medline TA:  J Exp Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1899-904     Citation Subset:  IM    
Rockefeller University, New York 10021, USA.
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MeSH Terms
Amino Acid Sequence
Antigen Presentation*
Antigens, Viral / metabolism*
Base Sequence
Gammaretrovirus / immunology*
Molecular Sequence Data
Subtilisins / metabolism
Superantigens / metabolism*
Tumor Cells, Cultured
Grant Support
Reg. No./Substance:
0/Antigens, Viral; 0/Superantigens; EC 3.4.21.-/Subtilisins; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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Journal Information
Journal ID (nlm-ta): J Exp Med
ISSN: 0022-1007
ISSN: 1540-9538
Publisher: The Rockefeller University Press
Article Information
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Print publication date: Day: 1 Month: 5 Year: 1995
Volume: 181 Issue: 5
First Page: 1899 Last Page: 1904
ID: 2192000
Publisher Id: 95239134
PubMed Id: 7722465

Proteolytic processing is required for viral superantigen activity

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