Document Detail


Proteolysis and phenylalanine hydroxylation in response to parenteral nutrition in extremely premature and normal newborns.
MedLine Citation:
PMID:  8609231     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To determine to what extent intravenous nutrition can reduce proteolysis in very immature and normal newborns, and to assess the capacity of preterm and normal newborns to convert phenylalanine to tyrosine, phenylalanine and leucine kinetics were measured under basal conditions and during parenteral nutrition in clinically stable, extremely premature (approximately 26 wk of gestation) infants and in normal term newborns. In response to parenteral nutrition, there was significantly less suppression (P < 0.001) of endogenous leucine and phenylalanine rate of appearance in extremely premature infants compared with term infants. Phenylalanine utilization for protein synthesis during parenteral nutrition increased significantly (P < 0.01) and by the same magnitude (approximately 15%) in both extremely premature and term infants. Phenylalanine was converted to tyrosine at substantial rates in both extremely premature and term infants; however, this conversion rate was significantly higher (P < 0.05) in extremely premature infants during both the basal and parenteral nutrition periods. These data provide clear evidence that there is no immaturity in the phenylalanine hydroxylation pathway. Furthermore, although parenteral nutrition appears to produce similar increases in protein synthesis in extremely premature and term infants, proteolysis is suppressed much less in extremely premature newborns. The factors responsible for this apparent resistance to suppression of proteolysis in the very immature newborn remain to be elucidated.
Authors:
S C Denne; C A Karn; J A Ahlrichs; A R Dorotheo; J Wang; E A Liechty
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of clinical investigation     Volume:  97     ISSN:  0021-9738     ISO Abbreviation:  J. Clin. Invest.     Publication Date:  1996 Feb 
Date Detail:
Created Date:  1996-05-29     Completed Date:  1996-05-29     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7802877     Medline TA:  J Clin Invest     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  746-54     Citation Subset:  AIM; IM    
Affiliation:
Department of Pediatrics, Indiana University School of Medicine, Indianapolis 46202, USA.
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MeSH Terms
Descriptor/Qualifier:
Amino Acids / blood
Blood Glucose / analysis
Female
Humans
Hydroxylation
Infant, Newborn
Infant, Premature / metabolism*
Insulin / blood
Kinetics
Male
Parenteral Nutrition*
Phenylalanine / metabolism*
Proteins / metabolism*
Tyrosine / biosynthesis*
Grant Support
ID/Acronym/Agency:
M-01RR750/RR/NCRR NIH HHS; P-60DK20542/DK/NIDDK NIH HHS; R01 HD-29153/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
0/Amino Acids; 0/Blood Glucose; 0/Proteins; 11061-68-0/Insulin; 55520-40-6/Tyrosine; 63-91-2/Phenylalanine
Comments/Corrections

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