| Proteolysis and antiproteolysis associated with toxemia of pregnancy. | |
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MedLine Citation:
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PMID: 7011239 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Ten pregnancy toxemia patients, 10 pregnant patients with essential arterial hypertension and 12 normal pregnant women were studied between the weeks 37 and 40 of gestation. From them blood samples were obtained 24 hours before and 24 hours and three months after the delivery. In these samples proteolytic (P) and antiproteolytic (AP) activities and alpha-1-antitrypsin (A1-AT) concentration were determined. The P and the AP were measured by hydrolysis of BAPNA, and the A1-AT by radial immunodiffusion. The most interesting results were observed 24 hours before the delivery. Toxemic patients presented increase of P and AP, and hypertensive patients diminution of A1-AT when compared with normal controls. These results demonstrated that in toxemia and essential hypertension during pregnancy maladjustments in mechanisms of serum proteolysis and antiproteolysis, perhaps related with the activation of complement, clotting and circulating immune complexes formation systems, exist. |
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Authors:
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C Vázquez Escobosa; R Pérez Medina; H Gómez Estrada; J Fernández de Castro |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Archivos de investigación médica Volume: 11 ISSN: 0066-6769 ISO Abbreviation: Arch Invest Med (Mex) Publication Date: 1980 |
Date Detail:
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Created Date: 1981-05-28 Completed Date: 1981-05-28 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0262036 Medline TA: Arch Invest Med (Mex) Country: MEXICO |
Other Details:
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Languages: eng; spa Pagination: 445-59 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Blood Proteins
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metabolism Female Humans Hypertension / enzymology* Peptide Hydrolases / blood* Pre-Eclampsia / enzymology* Pregnancy Pregnancy Complications, Cardiovascular / enzymology* Protease Inhibitors / blood* alpha 1-Antitrypsin / analysis |
| Chemical | |
Reg. No./Substance:
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0/Blood Proteins; 0/Protease Inhibitors; 0/alpha 1-Antitrypsin; EC 3.4.-/Peptide Hydrolases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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