| Proteolipid protein 2 is associated with melanoma metastasis. | |
| | |
MedLine Citation:
|
PMID: 20043097 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The metastasis of malignant tumor cells from the primary tumor to distant sites in the body is a complex process. To identify genes that may be essential for metastasis, we established poorly metastatic mouse melanoma cells, namely Y925F-mutated FAK-transfected cells (Y925F cells), from the highly metastatic mouse melanoma cell line B16F10, and performed expression analyses. The expression of phospholipid protein 2 (PLP2) was markedly down-regulated in the Y925F cells. To elucidate the function of PLP2, we established melanoma cells overexpressing PLP2. We found that PLP2 enhanced proliferation, adhesion, invasion, and MMP-2 secretion in vitro, and tumor metastasis in vivo. These results suggest that PLP2 aids metastasis. Furthermore, we showed that PLP2 binds specifically to PI3K, thus activating Akt. |
| | |
Authors:
|
Yoshiko Sonoda; Masako Warita; Takaharu Suzuki; Hiroki Ozawa; Yusuke Fukuda; Megumi Funakoshi-Tago; Tadashi Kasahara |
Related Documents
:
|
17487557 - Transcriptional profiling of human uveal melanoma from cell lines to intraocular tumors... 1657377 - Cell membrane signaling as target in cancer therapy. ii: inhibitory effect of n,n,n-tri... 10906637 - Advances in specific immunotherapy of malignant melanoma. 8727777 - Diffuse histiocytic lymphoma treated with chemotherapy and radiation. 544007 - Cytocidal effect of rifamycin derivatives on ascites tumor cells: studies with [125i]io... 6306627 - The regulation of vasopressin secretion in a patient with oat cell carcinoma of the bro... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Oncology reports Volume: 23 ISSN: 1791-2431 ISO Abbreviation: Oncol. Rep. Publication Date: 2010 Feb |
Date Detail:
|
Created Date: 2009-12-31 Completed Date: 2010-03-30 Revised Date: 2011-08-26 |
Medline Journal Info:
|
Nlm Unique ID: 9422756 Medline TA: Oncol Rep Country: Greece |
Other Details:
|
Languages: eng Pagination: 371-6 Citation Subset: IM |
Affiliation:
|
Faculty of Pharmacy, Keio University, Tokyo, Japan. sonoda-ys@pha.keio.ac.jp |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Cell Adhesion / genetics Cell Movement / genetics Enzyme Activation Gene Expression Regulation, Neoplastic Lung Neoplasms / genetics, secondary Matrix Metalloproteinase 2 / metabolism Melanoma, Experimental / genetics*, pathology* Mice Mice, Inbred C57BL Myelin Proteolipid Protein / genetics, metabolism, physiology* Neoplasm Metastasis Oncogene Protein v-akt / metabolism Phosphatidylinositol 3-Kinases / metabolism Rabbits Skin Neoplasms / genetics*, pathology* Tumor Cells, Cultured |
| Chemical | |
Reg. No./Substance:
|
0/Myelin Proteolipid Protein; 0/Plp2 protein, mouse; EC 2.7.1.-/Phosphatidylinositol 3-Kinases; EC 2.7.11.1/Oncogene Protein v-akt; EC 3.4.24.24/Matrix Metalloproteinase 2 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Pancreatic cancer therapy with a novel pump for controlled drug release.
Next Document: Fibroblasts from Werner syndrome patients: cancer cells derived by experimental introduction of onco...