Document Detail

Proteoglycans in cell regulation.
MedLine Citation:
PMID:  1418598     Owner:  NLM     Status:  MEDLINE    
Proteoglycans are a diverse group of proteins carrying one or more glycosaminoglycan side chains linked to the protein as O-glycosides. Our appreciation of these structures has matured from a curiosity about unusual structural glycoproteins, to confer upon them a central role in cell biology. The major classes of glycosaminoglycans are heparan sulfate and heparin, chondroitin and dermatan sulfates, keratan sulfate and hyaluronic acid. The latter is unique in that it does not contain sulfate residues, and appears to be synthesized, at least sometimes, free of a carrier protein. There is now a wealth of information on the ability of these structures to influence the growth and development of cells and tissues. Many direct and specific effects of proteoglycans will undoubtedly be found, and there are likely to be indirect effects of the glycosaminoglycans relating to their polyelectrolyte nature. Convincing arguments that biological activity resides in certain proteoglycan core proteins are also appearing. The following discussion concerns the role of proteoglycans in the regulation and action of autocrine and polypeptide growth factors, direct mitogenic and antimitogenic actions of glycosaminoglycans, the role of these structures in regulating gene expression, and the biological activities of proteoglycan core proteins. The probable role of proteoglycans in normal glomerular cell function, and in progressive renal disease, will be presented as a harbinger of the significant role we can expect them to play in diagnosis and therapy in the near future.
D M Templeton
Related Documents :
23345508 - Diversity of ubiquitin and isg15 specificity among nairoviruses' viral ovarian tumor do...
20961118 - Versatile polymer microspheres for injection therapy: aspects of fluoroscopic traceabil...
7151388 - Preparation and characterization of an antiserum against purified proteoglycan link pro...
3187328 - Electrical charge of a protein determines penetration and localization in hyaline artic...
19113808 - Phototocatalytic lithography of poly(propylene sulfide) block copolymers: toward high-t...
24270628 - Localization of arabinogalactan protein 6 fused with sirius ultramarine fluorescent pro...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Critical reviews in clinical laboratory sciences     Volume:  29     ISSN:  1040-8363     ISO Abbreviation:  Crit Rev Clin Lab Sci     Publication Date:  1992  
Date Detail:
Created Date:  1992-12-04     Completed Date:  1992-12-04     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8914816     Medline TA:  Crit Rev Clin Lab Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  141-84     Citation Subset:  IM    
Department of Clinical Biochemistry, University of Toronto, Canada.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Amino Acid Sequence
Cell Physiological Phenomena*
Fibroblast Growth Factors / chemistry,  physiology
Gene Expression Regulation / physiology
Glycosaminoglycans / physiology
Growth Substances / chemistry,  physiology
Kidney Diseases / therapy
Molecular Sequence Data
Peptides / physiology
Proteoglycans / classification,  physiology*
Reg. No./Substance:
0/Glycosaminoglycans; 0/Growth Substances; 0/Peptides; 0/Proteoglycans; 62031-54-3/Fibroblast Growth Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  The role of functional imaging in neoplasms of the thyroid.
Next Document:  Biochemistry of alcoholic liver disease.