Document Detail


Proteoglycans in cell regulation.
MedLine Citation:
PMID:  1418598     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Proteoglycans are a diverse group of proteins carrying one or more glycosaminoglycan side chains linked to the protein as O-glycosides. Our appreciation of these structures has matured from a curiosity about unusual structural glycoproteins, to confer upon them a central role in cell biology. The major classes of glycosaminoglycans are heparan sulfate and heparin, chondroitin and dermatan sulfates, keratan sulfate and hyaluronic acid. The latter is unique in that it does not contain sulfate residues, and appears to be synthesized, at least sometimes, free of a carrier protein. There is now a wealth of information on the ability of these structures to influence the growth and development of cells and tissues. Many direct and specific effects of proteoglycans will undoubtedly be found, and there are likely to be indirect effects of the glycosaminoglycans relating to their polyelectrolyte nature. Convincing arguments that biological activity resides in certain proteoglycan core proteins are also appearing. The following discussion concerns the role of proteoglycans in the regulation and action of autocrine and polypeptide growth factors, direct mitogenic and antimitogenic actions of glycosaminoglycans, the role of these structures in regulating gene expression, and the biological activities of proteoglycan core proteins. The probable role of proteoglycans in normal glomerular cell function, and in progressive renal disease, will be presented as a harbinger of the significant role we can expect them to play in diagnosis and therapy in the near future.
Authors:
D M Templeton
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Critical reviews in clinical laboratory sciences     Volume:  29     ISSN:  1040-8363     ISO Abbreviation:  Crit Rev Clin Lab Sci     Publication Date:  1992  
Date Detail:
Created Date:  1992-12-04     Completed Date:  1992-12-04     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8914816     Medline TA:  Crit Rev Clin Lab Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  141-84     Citation Subset:  IM    
Affiliation:
Department of Clinical Biochemistry, University of Toronto, Canada.
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MeSH Terms
Descriptor/Qualifier:
Amino Acid Sequence
Animals
Cell Physiological Phenomena*
Fibroblast Growth Factors / chemistry,  physiology
Gene Expression Regulation / physiology
Glycosaminoglycans / physiology
Growth Substances / chemistry,  physiology
Humans
Kidney Diseases / therapy
Molecular Sequence Data
Peptides / physiology
Proteoglycans / classification,  physiology*
Chemical
Reg. No./Substance:
0/Glycosaminoglycans; 0/Growth Substances; 0/Peptides; 0/Proteoglycans; 62031-54-3/Fibroblast Growth Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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