Document Detail

Proteoglycan synthesis in normotensive and spontaneously hypertensive rat arteries in vitro.
MedLine Citation:
PMID:  1435515     Owner:  NLM     Status:  MEDLINE    
Proteoglycans (PGs) were analyzed and compared in the media of the thoracic aorta, abdominal aorta, left carotid artery and superior mesenteric artery of age-matched Wistar-Kyoto (WKY) and spontaneously hypertensive (SHR) rats. Two ages were examined; 10 week old, during the development of hypertension and 28 week old, when hypertension is well established in the SHR. Large chondroitin sulfate PG, large heparan sulfate PG and biglycan (PGI) and decorin (PGII) small PGs were identified. Biglycan was the predominant small PG found in all arteries. Newly synthesized PGs were labelled in vitro with 35SO4 for quantitation. The synthesis of large and small PGs was similar in the media of the thoracic aorta, abdominal aorta, left carotid artery, and superior mesenteric artery. The large to small ratio value, a measure of the artery PG composition, was also similar among the four arteries but was highest in the mesenteric artery. In both WKY and SHR arteries there was significantly decreased PG synthesis in the 28-week old compared to 10-week old animals. This was especially true for large PG. Hypertensive changes in PG synthesis were seen mainly in the carotid artery. In this artery, synthesis of both large and small PG was increased in the SHR, at both ages. The ratio of large to small PG was not significantly different between SHR and WKY arteries. We conclude that 28-week old WKY and SHR rat arteries synthesize less large and small PG than 10-week old arteries. The most prominent change seen in hypertensive rats is an increase in PG synthesis in the carotid artery.
H M Walker-Caprioglio; T J Koob; L J McGuffee
Related Documents :
12552635 - Embryonic origin of the caudal mesenteric artery in the mouse.
6476575 - Transruminal palpation of abdominal arteries of the permanently fistulated dairy cow.
8827035 - Mucosal biopsy findings and venous abnormalities in idiopathic myointimal hyperplasia o...
6305125 - Temporary intestinal ischaemia induced by proximal mesenteric artery occlusion.
2350635 - Anatomical study of the recurrent flaps of the upper arm.
230325 - The co2 laser beam in the surgical treatment of cerebral tumours.
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Matrix (Stuttgart, Germany)     Volume:  12     ISSN:  0934-8832     ISO Abbreviation:  Matrix     Publication Date:  1992 Aug 
Date Detail:
Created Date:  1992-12-02     Completed Date:  1992-12-02     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8906139     Medline TA:  Matrix     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  308-20     Citation Subset:  IM    
Department of Pharmacology, University of New Mexico School of Medicine, Albuquerque 87131.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Aorta / metabolism*
Aorta, Abdominal / metabolism
Aorta, Thoracic / metabolism
Carotid Arteries / metabolism*
Glycosaminoglycans / biosynthesis*
Hypertension / metabolism*
Mesenteric Arteries / metabolism*
Muscle, Smooth, Vascular / metabolism*
Proteoglycans / biosynthesis*
Rats, Inbred SHR / metabolism*
Rats, Inbred WKY / metabolism
Grant Support
Reg. No./Substance:
0/Glycosaminoglycans; 0/Proteoglycans

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Studies of collagen in bone and dentin matrix of a Columbian mammoth (late Pleistocene) of central U...
Next Document:  In-situ hybridization of tropoelastin mRNA during the development of the multilayered neonatal rat a...