Document Detail


Proteoglycan synthesis in normotensive and spontaneously hypertensive rat arteries in vitro.
MedLine Citation:
PMID:  1435515     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Proteoglycans (PGs) were analyzed and compared in the media of the thoracic aorta, abdominal aorta, left carotid artery and superior mesenteric artery of age-matched Wistar-Kyoto (WKY) and spontaneously hypertensive (SHR) rats. Two ages were examined; 10 week old, during the development of hypertension and 28 week old, when hypertension is well established in the SHR. Large chondroitin sulfate PG, large heparan sulfate PG and biglycan (PGI) and decorin (PGII) small PGs were identified. Biglycan was the predominant small PG found in all arteries. Newly synthesized PGs were labelled in vitro with 35SO4 for quantitation. The synthesis of large and small PGs was similar in the media of the thoracic aorta, abdominal aorta, left carotid artery, and superior mesenteric artery. The large to small ratio value, a measure of the artery PG composition, was also similar among the four arteries but was highest in the mesenteric artery. In both WKY and SHR arteries there was significantly decreased PG synthesis in the 28-week old compared to 10-week old animals. This was especially true for large PG. Hypertensive changes in PG synthesis were seen mainly in the carotid artery. In this artery, synthesis of both large and small PG was increased in the SHR, at both ages. The ratio of large to small PG was not significantly different between SHR and WKY arteries. We conclude that 28-week old WKY and SHR rat arteries synthesize less large and small PG than 10-week old arteries. The most prominent change seen in hypertensive rats is an increase in PG synthesis in the carotid artery.
Authors:
H M Walker-Caprioglio; T J Koob; L J McGuffee
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Matrix (Stuttgart, Germany)     Volume:  12     ISSN:  0934-8832     ISO Abbreviation:  Matrix     Publication Date:  1992 Aug 
Date Detail:
Created Date:  1992-12-02     Completed Date:  1992-12-02     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8906139     Medline TA:  Matrix     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  308-20     Citation Subset:  IM    
Affiliation:
Department of Pharmacology, University of New Mexico School of Medicine, Albuquerque 87131.
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MeSH Terms
Descriptor/Qualifier:
Animals
Aorta / metabolism*
Aorta, Abdominal / metabolism
Aorta, Thoracic / metabolism
Carotid Arteries / metabolism*
Glycosaminoglycans / biosynthesis*
Hypertension / metabolism*
Mesenteric Arteries / metabolism*
Muscle, Smooth, Vascular / metabolism*
Proteoglycans / biosynthesis*
Rats
Rats, Inbred SHR / metabolism*
Rats, Inbred WKY / metabolism
Grant Support
ID/Acronym/Agency:
HL37015/HL/NHLBI NIH HHS; RR08139/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Glycosaminoglycans; 0/Proteoglycans

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