Document Detail


Proteinuria in obstructive sleep apnea.
MedLine Citation:
PMID:  11576363     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Previous studies have reported an association between obstructive sleep apnea (OSA) and proteinuria, but are limited in their ability to assess proteinuria accurately, to adjust for confounders such as obesity, or to exclude confidently underlying renal disease in patients with OSA and nephrotic-range proteinuria. METHODS: The spot urine protein/creatinine ratio was measured in a prospective consecutive series of 148 patients referred for polysomnography who were not diabetic and had not been treated previously for OSA. The urine protein/creatinine ratio was compared across four levels of OSA severity, based on the frequency of apneas and hypopneas per hour: <5 (absent), 5 to 14.9 (mild), 15 to 29.9 (moderate), and > or =30 (severe). RESULTS: The median level of urine protein/creatinine ratio in all categories of OSA was <0.2 (range 0.03 to 0.69; median 0.06 in patients with normal apnea hypopnea index, 0.06, 0.07, 0.07 in patients with mild, moderate, and severe OSA, respectively). Eight subjects had a urine protein/creatinine ratio greater than 0.2. Univariate analysis showed a significant association between urine protein/creatinine ratio and older age (P < 0.0001), hypertension (P < 0.0001), coronary artery disease (P = 0.003), and arousal index (P = 0.003). Body mass index (P = 0.16), estimated creatinine clearance (P = 0.17), and apnea hypopnea index (P = 0.13) were not associated with the urine protein/creatinine ratio. In multiple regression analysis, only age and hypertension were independent positive predictors of the urine protein/creatinine ratio (P < 0.0001, R2 = 0.17). CONCLUSION: Clinically significant proteinuria is uncommon in sleep apnea. Nephrotic range proteinuria should not be ascribed to sleep apnea and deserves a thorough renal evaluation.
Authors:
L F Casserly; N Chow; S Ali; D J Gottlieb; L J Epstein; J S Kaufman
Related Documents :
22472633 - Sleep and television and computer habits of swedish school-age children.
19968043 - Clinical presentation of obstructive sleep apnea in patients with end-stage renal disease.
10321523 - Inter-subject variability and normal limits of the sita standard, sita fast, and the hu...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Kidney international     Volume:  60     ISSN:  0085-2538     ISO Abbreviation:  Kidney Int.     Publication Date:  2001 Oct 
Date Detail:
Created Date:  2001-09-28     Completed Date:  2002-01-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0323470     Medline TA:  Kidney Int     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1484-9     Citation Subset:  IM    
Affiliation:
Renal Units, Evans Memorial Department of Medicine, Boston University School of Medicine and VA Boston Healthcare System, Boston, Massachusetts, USA. lfc@bu.edu
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Boston
Creatinine / blood,  urine
Cross-Sectional Studies
Humans
Middle Aged
Nephrotic Syndrome / urine
Prevalence
Prospective Studies
Proteinuria / blood,  complications*,  epidemiology,  urine
Sleep Apnea Syndromes / blood,  urine*
Chemical
Reg. No./Substance:
60-27-5/Creatinine
Comments/Corrections
Comment In:
Kidney Int. 2002 Apr;61(4):1551   [PMID:  11918770 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Outcome of living unrelated (commercial) renal transplantation.
Next Document:  Severity of renal vascular disease predicts mortality in patients undergoing coronary angiography.