Document Detail

Proteinuria in autoimmune thyroid disease.
MedLine Citation:
PMID:  3839619     Owner:  NLM     Status:  MEDLINE    
We have investigated the prevalence of proteinuria in patients with Graves' disease and chronic autoimmune thyroiditis attending a routine thyroid clinic. Using the urine protein creatinine index, proteinuria was found in 29.8% of patients with autoimmune thyroid disease and in 9.5% of patients attending the same clinic but without these conditions. When patients with Graves' disease were treated with 131I, proteinuria measured by 24 h collections developed in 9 of 14 patients without pre-existing proteinuria and appeared to diminish in 4 patients in whom proteinuria had been present before treatment. The prevalence and fluctuation of proteinuria was independent of thyroglobulin and microsomal antibody levels. We were unable to confirm previous reports of a high prevalence of circulating immune complexes in autoimmune thyroid disease; complexes were detected in only 7.9% of patients and did not correlate with proteinuria. The causes of mild proteinuria in autoimmune thyroid disease are not apparent, but previous case reports suggesting that membranous glomerulonephritis is associated with Graves' disease, albeit rarely, indicate that immunological mechanisms may be implicated.
A P Weetman; K Tomlinson; N Amos; J H Lazarus; R Hall; A M McGregor
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta endocrinologica     Volume:  109     ISSN:  0001-5598     ISO Abbreviation:  Acta Endocrinol.     Publication Date:  1985 Jul 
Date Detail:
Created Date:  1985-09-09     Completed Date:  1985-09-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370312     Medline TA:  Acta Endocrinol (Copenh)     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  341-7     Citation Subset:  IM    
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MeSH Terms
Antigen-Antibody Complex / analysis
Autoimmune Diseases / complications*
Creatinine / urine
Graves Disease / complications*,  urine
Iodine Radioisotopes / therapeutic use
Middle Aged
Proteinuria / etiology*
Thyroiditis / complications*,  immunology,  urine
Reg. No./Substance:
0/Antigen-Antibody Complex; 0/Iodine Radioisotopes; 60-27-5/Creatinine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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