Document Detail

Proteinuria as a significant determinant of hypertension in a normotensive screened cohort in Okinawa, Japan.
MedLine Citation:
PMID:  17249524     Owner:  NLM     Status:  MEDLINE    
To evaluate the influence of proteinuria on the development of hypertension in normotensive screened subjects. We studied 4,428 normotensive subjects without heart disease (2888 men, 1540 women, age 19-89 years) who were participants in a 1-day health evaluation in both 1997 and 2000. The 3-year frequency of developing hypertension was 6.0% in subjects without proteinuria, and 13.5% in subjects with proteinuria. The odds ratio for developing hypertension by age (year) increased approximately 1.6%. Obesity was associated with an approximately 40% increased risk of hypertension; proteinuria increased the risk of hypertension 2-fold. Proteinuria was a significant predictor of developing hypertension. Age, obesity, and initial blood pressure level also contributed to the development of hypertension. In conclusion, proteinuria is a powerful predictor of developing hypertension. Age and obesity are also associated with increased risk of hypertension. Lifestyle modification might thus be necessary, particularly in subjects with proteinuria.
Taku Inoue; Kunitoshi Iseki; Yasushi Higashiuesato; Kazufumi Nagahama; Mitsuteru Matsuoka; Chiho Iseki; Yusuke Ohya; Kozen Kinjo; Shuichi Takishita
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Hypertension research : official journal of the Japanese Society of Hypertension     Volume:  29     ISSN:  0916-9636     ISO Abbreviation:  Hypertens. Res.     Publication Date:  2006 Sep 
Date Detail:
Created Date:  2007-01-25     Completed Date:  2007-02-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9307690     Medline TA:  Hypertens Res     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  687-93     Citation Subset:  IM    
Cardiovascular Division, Heart Life Hospital, Okinawa, Japan.
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MeSH Terms
Aged, 80 and over
Hypertension / etiology*
Middle Aged
Proteinuria / complications*
Risk Factors

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