Document Detail

Proteins involved in establishment and maintenance of imprinted methylation marks.
MedLine Citation:
PMID:  22760206     Owner:  NLM     Status:  MEDLINE    
Epigenetic phenomena are being increasingly recognized to play key roles in normal mammalian development and disease. This is exemplified by the process of genomic imprinting whereby despite identical DNA sequence, the two parental chromosomes are not equivalent and show either maternal- or paternal-specific expression at a subset of genes in the genome. These patterns are set up by differential DNA methylation marking at the imprinting control regions in male and female germ line. In this review, we discuss the specific mechanisms by which these methyl marks are established and then selectively maintained throughout pre-implantation development. Specifically, we discuss the recent findings of a critical role played by a KRAB zinc-finger protein ZFP57 and its co-factor KAP1/TRIM28 in mediating both processes.
Ruslan Strogantsev; Anne C Ferguson-Smith
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Briefings in functional genomics     Volume:  11     ISSN:  2041-2657     ISO Abbreviation:  Brief Funct Genomics     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-07-04     Completed Date:  2012-10-23     Revised Date:  2014-02-24    
Medline Journal Info:
Nlm Unique ID:  101528229     Medline TA:  Brief Funct Genomics     Country:  England    
Other Details:
Languages:  eng     Pagination:  227-39     Citation Subset:  IM    
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MeSH Terms
DNA Methylation
Genomic Imprinting*
Germ Cells / physiology
Histones / metabolism
Models, Biological
Proteins / genetics*,  metabolism
Zinc Fingers
Grant Support
079249//Wellcome Trust; BB/GO20930/1//Biotechnology and Biological Sciences Research Council; MR/J001597/1//Medical Research Council
Reg. No./Substance:
0/Histones; 0/Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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