Document Detail

Proteins associated with the early intrauterine equine conceptus.
MedLine Citation:
PMID:  18638129     Owner:  NLM     Status:  MEDLINE    
A critical period of early gestation in the mare involves the immobilization (fixation) of the encapsulated conceptus at around days 16-17. We compared the major proteins in the normal equine embryonic capsule and endometrial secretions around the period of fixation with those from pregnancies in the process of termination induced by administration of an analogue of prostaglandin F(2 alpha) (PGF(2 alpha)). Uterocalin and beta(2)-microglobulin (beta(2)M) associated with the embryonic capsule were proteolytically converted to smaller forms during the fixation period. These conversions were similar in conceptuses from control and treated mares. A 17 kDa cationic protein identified as a secretory phospholipase A2 (sPLA2) type IIA was detected bound to normal capsules but increased substantially in response to PGF(2 alpha). Two forms of uteroglobin were distinguished by partial amino acid sequences of approximately 6 kDa bands in flush fluids from normal pregnant uteri. After administration of PGF(2 alpha) one immunoreactive form of uteroglobin was preferentially increased. These studies demonstrate that failure of pregnancy in this model is associated with an increase in secretory phospholipase in the capsule and a change in the forms of uteroglobin in the uterine secretions.
M A Hayes; B A Quinn; N D Keirstead; P Katavolos; R O Waelchli; K J Betteridge
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Reproduction in domestic animals = Zuchthygiene     Volume:  43 Suppl 2     ISSN:  1439-0531     ISO Abbreviation:  Reprod. Domest. Anim.     Publication Date:  2008 Jul 
Date Detail:
Created Date:  2008-07-21     Completed Date:  2008-12-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9015668     Medline TA:  Reprod Domest Anim     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  232-7     Citation Subset:  IM    
Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, ON, Canada.
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MeSH Terms
Electrophoresis, Polyacrylamide Gel
Embryo Implantation / physiology*
Embryo, Mammalian / metabolism*
Gestational Age
Glycoproteins / analysis,  metabolism*
Horses / metabolism,  physiology*
Pregnancy, Animal / metabolism,  physiology*
Uteroglobin / analysis,  metabolism
Uterus / chemistry,  metabolism
Yolk Sac / chemistry,  metabolism
beta 2-Microglobulin / analysis,  metabolism
Reg. No./Substance:
0/Glycoproteins; 0/beta 2-Microglobulin; 9060-09-7/Uteroglobin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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