Document Detail

Protein:creatinine ratio in uncomplicated twin pregnancy.
MedLine Citation:
PMID:  20691965     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Women with twin pregnancies may have higher rates of isolated proteinuria than do those with singletons. We compared protein-to-creatinine (P:C) ratios longitudinally through gestation in uncomplicated twin and singleton pregnancies. STUDY DESIGN: P:C ratios were compared at 3 times points in 102 (51 twins, 51 singletons) healthy gravid patients who did not have preeclampsia develop, using linear and logistic regression techniques. RESULTS: P:C ratio increased significantly over gestation in all patients. This increase was significantly greater in twins than in singletons. The odds of P:C ratio >0.19 was 3.5 times higher in twins between 34 and 38 weeks. CONCLUSION: Women with uncomplicated twin pregnancies have greater protein excretion as measured by P:C ratios than do those with singletons. In early pregnancy, protein excretion is similar, but it diverges significantly by the latter third trimester. We suggest that normal values for proteinuria in twins may differ from those in singletons, and warrant further evaluation.
Nicole A Smith; Jennifer G Lyons; Thomas F McElrath
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Publication Detail:
Type:  Comparative Study; Journal Article; Multicenter Study     Date:  2010-08-09
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  203     ISSN:  1097-6868     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-09-29     Completed Date:  2010-11-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  381.e1-4     Citation Subset:  AIM; IM    
Copyright Information:
Copyright © 2010 Mosby, Inc. All rights reserved.
Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Brigham and Women's Hospital, Boston, MA 02115, USA.
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MeSH Terms
Body Mass Index
Creatinine / urine*
Gestational Age
Logistic Models
Pregnancy, Multiple*
Prospective Studies
Proteinuria / epidemiology*
Reproductive Techniques, Assisted
Smoking / adverse effects
Reg. No./Substance:

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