Document Detail


Proteinases in rheumatoid arthritis.
MedLine Citation:
PMID:  1613735     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The role of proteinases in the extracellular breakdown of the connective tissue matrix during disease processes is outlined. Focussing on the matrix metalloproteinases, we present an overview of the mechanisms regulating their activity. Methods of assessing their role in disease processes is exemplified by new data on stromelysin activity in remodelling joint tissues in both model systems and human disease.
Authors:
G Murphy; R M Hembry
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of rheumatology. Supplement     Volume:  32     ISSN:  0380-0903     ISO Abbreviation:  J Rheumatol Suppl     Publication Date:  1992 Jan 
Date Detail:
Created Date:  1992-07-30     Completed Date:  1992-07-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7806058     Medline TA:  J Rheumatol Suppl     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  61-4     Citation Subset:  IM    
Affiliation:
Cell and Molecular Biology Department, Strangeways Research Laboratory, Cambridge, UK.
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MeSH Terms
Descriptor/Qualifier:
Animals
Arthritis / enzymology
Arthritis, Rheumatoid / enzymology*,  pathology
Extracellular Matrix / pathology
Glycoproteins / physiology
Humans
Matrix Metalloproteinase 3
Metalloendopeptidases / metabolism,  physiology*
Proteoglycans / metabolism
Tissue Inhibitor of Metalloproteinases
Chemical
Reg. No./Substance:
0/Glycoproteins; 0/Proteoglycans; 0/Tissue Inhibitor of Metalloproteinases; EC 3.4.24.-/Metalloendopeptidases; EC 3.4.24.17/Matrix Metalloproteinase 3

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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