Document Detail

Protein turnover in pregnancy.
MedLine Citation:
PMID:  1639049     Owner:  NLM     Status:  MEDLINE    
Whole-body protein metabolism was studied at 13, 24 and 35 weeks gestation in six healthy women using a continuous infusion [13C]leucine technique. Values were expressed in terms of fat-free body weight (FFM) calculated using literature standards for changes in total body potassium during pregnancy. Mean protein synthesis increased from 5.3 (+/- 0.6 SD) g/kg FFM/24h at 13 weeks to 5.9 +/- 0.5 (P less than 0.1) at 24 weeks and 6.1 +/- 0.6 at 35 weeks (P less than 0.05 vs 3 weeks). Similar increases were noted in catabolism so that net loss changed little. Protein synthesis at 24 and 35 weeks gestations was significantly greater than that in 17 healthy, non-pregnant women (4.9 +/- 0.6, P less than 0.001). These data indicate that there are substantial increases in protein turnover during pregnancy.
G N Thompson; D Halliday
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of clinical nutrition     Volume:  46     ISSN:  0954-3007     ISO Abbreviation:  Eur J Clin Nutr     Publication Date:  1992 Jun 
Date Detail:
Created Date:  1992-09-02     Completed Date:  1992-09-02     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8804070     Medline TA:  Eur J Clin Nutr     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  411-7     Citation Subset:  IM    
Nutrition Research Group, Clinical Research Centre, Harrow, UK.
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MeSH Terms
Adipose Tissue / chemistry
Age Factors
Body Composition
Body Mass Index
Body Weight
Carbon Isotopes
Evaluation Studies as Topic
Infusions, Intravenous
Leucine / administration & dosage
Middle Aged
Pregnancy / metabolism*
Pregnancy Trimester, First
Pregnancy Trimester, Second
Pregnancy Trimester, Third
Protein Biosynthesis
Proteins / metabolism*
Reference Values
Reg. No./Substance:
0/Carbon Isotopes; 0/Proteins; 61-90-5/Leucine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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