| Protein synthesis upon acute nutrient restriction relies on proteasome function. | |
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MedLine Citation:
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PMID: 16373576 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The mechanisms that protect mammalian cells against amino acid deprivation are only partially understood. We found that during an acute decrease in external amino acid supply, before up-regulation of the autophagosomal-lysosomal pathway, efficient translation was ensured by proteasomal protein degradation. Amino acids for the synthesis of new proteins were supplied by the degradation of preexisting proteins, whereas nascent and newly formed polypeptides remained largely protected from proteolysis. Proteasome inhibition during nutrient deprivation caused rapid amino acid depletion and marked impairment of translation. Thus, the proteasome plays a crucial role in cell survival after acute disruption of amino acid supply. |
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Authors:
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Ramunas M Vabulas; F Ulrich Hartl |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Science (New York, N.Y.) Volume: 310 ISSN: 1095-9203 ISO Abbreviation: Science Publication Date: 2005 Dec |
Date Detail:
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Created Date: 2005-12-23 Completed Date: 2006-01-04 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 0404511 Medline TA: Science Country: United States |
Other Details:
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Languages: eng Pagination: 1960-3 Citation Subset: IM |
Affiliation:
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Department of Cellular Biochemistry, Max Planck Institute of Biochemistry, Am Klopferspitz 18, D-82152 Martinsried, Germany. vabulas@biochem.mpg.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acids
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metabolism* Azetidinecarboxylic Acid / metabolism Cell Line Green Fluorescent Proteins / genetics Hela Cells Humans Proteasome Endopeptidase Complex / antagonists & inhibitors, physiology* Protein Biosynthesis / physiology* Protein Kinases / metabolism Ubiquitin / genetics |
| Chemical | |
Reg. No./Substance:
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0/Amino Acids; 0/Ubiquitin; 147336-22-9/Green Fluorescent Proteins; 2517-04-6/Azetidinecarboxylic Acid; EC 2.7.-/Protein Kinases; EC 3.4.25.1/Proteasome Endopeptidase Complex |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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